{"id":"W2997064696","doi":"10.1002/lary.28441","title":"Apoptosis signaling molecules as treatment targets in head and neck squamous cell carcinoma","year":2020,"lang":"en","type":"article","venue":"The Laryngoscope","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Center for Advancing Translational Sciences; American Laryngological, Rhinological and Otological Society; National Institute of Dental and Craniofacial Research; National Institute on Aging; National Cancer Institute; Pershing Square Sohn Cancer Research Alliance","keywords":"MCL1; Head and neck squamous-cell carcinoma; Apoptosis; Bortezomib; Cancer research; Cell; Cell culture; Annexin A5; Biology; Annexin; Programmed cell death; Cancer; Head and neck cancer; Medicine; Internal medicine; Downregulation and upregulation; Immunology; Multiple myeloma; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005050094,0.0001329783,0.0001184406,0.00001531534,0.00007100805,0.00002097766,0.00008175306,0.00007772689,0.00002329566],"category_scores_gemma":[0.000009334502,0.00009299599,0.00004494555,0.00006184954,0.00002595496,0.000002696772,0.00006647468,0.0000459625,0.00001192637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001081094,"about_ca_system_score_gemma":0.00002719613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001973096,"about_ca_topic_score_gemma":0.00003025184,"domain_scores_codex":[0.9993419,0.00004979159,0.0001216865,0.0002513966,0.00006685445,0.0001683931],"domain_scores_gemma":[0.9997301,0.000008328057,0.00003668254,0.000139841,0.00001355397,0.00007154091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009682871,0.00004723873,0.00104326,0.00001708199,0.000006802022,0.000005463769,0.0003715816,0.0002925455,0.9967083,0.00005767887,0.00007561856,0.001277579],"study_design_scores_gemma":[0.0009904592,0.0008895919,0.001924404,0.000004931775,0.00002068676,0.000004007187,0.0001017565,0.0008669042,0.989979,0.00008175404,0.005001211,0.000135315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941272,0.003572936,0.000286987,0.0007999099,0.00003603881,0.0002343676,0.000005168812,0.000008608917,0.0009288264],"genre_scores_gemma":[0.9982882,0.000232276,0.0003830868,0.0006370152,0.0001126367,0.00001747039,0.0000488668,0.00001831449,0.0002621915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006729343,"threshold_uncertainty_score":0.3792266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228404880075126,"score_gpt":0.2296317281822459,"score_spread":0.2173476793814947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}