{"id":"W2997064696","doi":"10.1002/lary.28441","title":"Apoptosis signaling molecules as treatment targets in head and neck squamous cell carcinoma","year":2020,"lang":"en","type":"article","venue":"The Laryngoscope","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Center for Advancing Translational Sciences; American Laryngological, Rhinological and Otological Society; National Institute of Dental and Craniofacial Research; National Institute on Aging; National Cancer Institute; Pershing Square Sohn Cancer Research Alliance","keywords":"MCL1; Head and neck squamous-cell carcinoma; Apoptosis; Bortezomib; Cancer research; Cell; Cell culture; Annexin A5; Biology; Annexin; Programmed cell death; Cancer; Head and neck cancer; Medicine; Internal medicine; Downregulation and upregulation; Immunology; Multiple myeloma; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005077324,0.000306173,0.0005881008,0.0008757801,0.0002172072,0.0006927569,0.0003173384,0.00031123,0.001133701],"category_scores_gemma":[0.0004405916,0.00009407518,0.0003756623,0.00117546,0.0001548044,0.0002767752,0.0002663285,0.0003289795,0.0002446308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001135505,"about_ca_system_score_gemma":0.0009586539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002931228,"about_ca_topic_score_gemma":0.007209829,"domain_scores_codex":[0.9996849,0.00004987388,0.00002918961,0.00005414601,0.0001349841,0.00004685696],"domain_scores_gemma":[0.9998223,0.00002470036,0.00005620193,0.00001009564,0.00006866272,0.00001796052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005004108,0.0006756164,0.4209492,0.003179416,0.0007662947,0.0005689348,0.0001718701,0.004486976,0.2523339,0.0003704453,0.004805176,0.306688],"study_design_scores_gemma":[0.0005553814,0.004186936,0.7941785,0.0004217828,0.001469883,0.001875943,0.0005805279,0.006605045,0.1548906,0.0006187814,0.03457487,0.00004178577],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.934689,0.05719133,0.0009909583,0.0005396258,0.00005197923,0.0002016184,0.003664688,0.0001220842,0.002548694],"genre_scores_gemma":[0.9827095,0.01050354,0.00136626,0.0002014861,0.00003027343,0.0001317436,0.004239583,0.00001025649,0.0008073974],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002931228,"threshold_uncertainty_score":0.008238673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228404880075126,"score_gpt":0.2296317281822459,"score_spread":0.2173476793814947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}