{"id":"W2997218091","doi":"10.1016/j.canlet.2019.12.025","title":"miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA","year":2019,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Ontario Institute for Cancer Research; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada; Friends of the Cancer Centre; Ontario Ministry of Research, Innovation and Science; Government of Ontario; Ontario Institute for Cancer Research; Public Health Agency; Movember Foundation","keywords":"Prostate cancer; Gene knockdown; Radioresistance; Medicine; Radiation therapy; Retinoid X receptor; Cancer research; Oncology; Prostate; Cancer; microRNA; Internal medicine; Nuclear receptor; Biology; Cell culture; Transcription factor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004552435,0.0001215501,0.0001234055,0.00001796387,0.00002872827,0.00001454781,0.0001098728,0.00005923953,0.00005189624],"category_scores_gemma":[0.000008955085,0.0001020537,0.00003765109,0.0000931059,0.00006883606,0.00001670697,0.00001911504,0.00007821438,0.000004321484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005533158,"about_ca_system_score_gemma":0.0001142423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008426043,"about_ca_topic_score_gemma":0.00005887699,"domain_scores_codex":[0.9992643,0.0000252841,0.000146154,0.0002853554,0.0001207824,0.0001581326],"domain_scores_gemma":[0.9995139,0.000006748252,0.0001689071,0.0002132447,0.00007520895,0.000021969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002997489,0.00001403411,0.01990415,0.0002559149,0.00006447482,0.000001147963,0.0003351503,0.0005527145,0.9730468,0.00001447885,0.004581628,0.0009297465],"study_design_scores_gemma":[0.0005314244,0.00008531099,0.001095571,0.0001500553,0.00002148612,0.00000168355,0.00006221915,0.00001375853,0.9205101,0.00001049747,0.07736371,0.0001541797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941733,0.002881576,0.0003793763,0.001321155,0.0002653793,0.0002779312,0.00001925774,0.000009717603,0.0006723153],"genre_scores_gemma":[0.9960083,0.0009012383,0.0003649158,0.0008970936,0.0001739884,0.0001151821,0.00005307549,0.00002346721,0.001462741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07278208,"threshold_uncertainty_score":0.4161628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005768838125247722,"score_gpt":0.2477922745350722,"score_spread":0.2420234364098245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}