{"id":"W2997218091","doi":"10.1016/j.canlet.2019.12.025","title":"miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA","year":2019,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Ontario Institute for Cancer Research; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada; Friends of the Cancer Centre; Ontario Ministry of Research, Innovation and Science; Government of Ontario; Ontario Institute for Cancer Research; Public Health Agency; Movember Foundation","keywords":"Prostate cancer; Gene knockdown; Radioresistance; Medicine; Radiation therapy; Retinoid X receptor; Cancer research; Oncology; Prostate; Cancer; microRNA; Internal medicine; Nuclear receptor; Biology; Cell culture; Transcription factor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072441,0.0001503624,0.0001726683,0.0001362911,0.0001570911,0.00040397,0.0001104115,0.000185356,0.00229283],"category_scores_gemma":[0.0001622516,0.0001203741,0.0002107755,0.00009818307,0.0001626939,0.00009193057,0.0001509607,0.000403306,0.00067999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000230996,"about_ca_system_score_gemma":0.0001219982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002500856,"about_ca_topic_score_gemma":0.0003856056,"domain_scores_codex":[0.9998881,0.00002821989,0.000006990558,0.00002586658,0.00003216221,0.00001864481],"domain_scores_gemma":[0.9999223,0.00001577204,0.00003091487,0.000008410248,0.000007557109,0.00001514964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004320497,0.00004277574,0.003765516,0.00007925294,0.00002732446,0.0001985325,0.00002669994,0.0002034626,0.9881784,0.0002865222,0.0004756796,0.006283766],"study_design_scores_gemma":[0.00006823302,0.0008040977,0.07379156,0.00002026626,0.0001030048,0.00242842,0.0001263873,0.002833411,0.8968593,0.0004206047,0.02252256,0.00002214146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814913,0.008447969,0.004233452,0.0008277862,0.00009664515,0.00002258995,0.0003808045,0.0002775451,0.004221969],"genre_scores_gemma":[0.9951724,0.0014108,0.001031225,0.0001498954,0.00002184894,0.000008844642,0.0002196407,0.00002306666,0.001962147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00229283,"threshold_uncertainty_score":0.007670343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005768838125247722,"score_gpt":0.2477922745350722,"score_spread":0.2420234364098245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}