{"id":"W2997218855","doi":"10.1038/s41594-019-0357-0","title":"A bipartite structural organization defines the SERINC family of HIV-1 restriction factors","year":2020,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Medical Research Council; Francis Crick Institute; Wellcome Trust","keywords":"Biology; Mutagenesis; Transmembrane protein; Protein structure; Cell biology; Subfamily; Transmembrane domain; Viral envelope; Glycoprotein; Biophysics; Chemistry; Genetics; Mutation; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001870117,0.0003831745,0.0002478969,0.0005488871,0.0006723038,0.0008072093,0.0003497534,0.000287783,0.001888418],"category_scores_gemma":[0.000293183,0.000226983,0.0002985573,0.0004338943,0.0004436608,0.0004173942,0.0003669733,0.0007008437,0.001208536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000494516,"about_ca_system_score_gemma":0.0005283603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007109996,"about_ca_topic_score_gemma":0.001137411,"domain_scores_codex":[0.9998525,0.00002232624,0.000008880255,0.00003677213,0.00003867471,0.00004075019],"domain_scores_gemma":[0.9996248,0.00005976003,0.00008699645,0.00004436167,0.00006492763,0.0001191048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004344159,0.00005654233,0.002670142,0.00008853758,0.00001343102,0.0002569951,0.00008989129,0.0003914968,0.9739127,0.008775496,0.0006425469,0.01266786],"study_design_scores_gemma":[0.0001008257,0.001064175,0.07599958,0.00008916639,0.00008873893,0.005478112,0.0006234517,0.01177584,0.8178922,0.01415826,0.07259297,0.0001366895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663009,0.00151472,0.02010282,0.0001826796,0.00005673485,0.0000572124,0.0005984588,0.0004155887,0.01077081],"genre_scores_gemma":[0.9754879,0.0005738194,0.01760747,0.0002340656,0.00004449613,0.00003093946,0.001855426,0.00008131732,0.004084422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888418,"threshold_uncertainty_score":0.006317437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008169920025398828,"score_gpt":0.2689148983673804,"score_spread":0.2607449783419815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}