{"id":"W2997220156","doi":"10.1200/jco.19.02393","title":"Value of Biomarker Expression for Randomized Clinical Trial Design: One (More) Missed Opportunity","year":2019,"lang":"en","type":"letter","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Biomarker; Randomized controlled trial; Value (mathematics); Oncology; Internal medicine; Statistics; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.1970084,0.001303362,0.007475421,0.001640556,0.002040776,0.008191733,0.005122208,0.03337302,0.007774855],"category_scores_gemma":[0.4616065,0.001455393,0.003516721,0.001661808,0.01203829,0.0104132,0.003389162,0.04472589,0.004776013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005203394,"about_ca_system_score_gemma":0.006208334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009962802,"about_ca_topic_score_gemma":0.001798715,"domain_scores_codex":[0.777698,0.1802904,0.01497002,0.007697188,0.01781172,0.001532604],"domain_scores_gemma":[0.2763443,0.6629967,0.01101642,0.01464167,0.02554078,0.009460111],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.006077867,0.0003697135,0.007727185,0.001862176,0.001525977,0.001434802,0.0004236899,0.001415107,0.000764378,0.0413998,0.7116809,0.2253184],"study_design_scores_gemma":[0.01029062,0.003134685,0.007268609,0.005484434,0.001484099,0.003853104,0.0006701004,0.01402743,0.001519362,0.3745594,0.5768065,0.0009017179],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.000802121,0.008840037,0.004678221,0.9597455,0.02399237,0.00009368282,0.0001536418,0.00007288105,0.0016216],"genre_scores_gemma":[0.01870155,0.004035655,0.01647937,0.7846146,0.1743181,0.0005057637,0.0000896027,0.00009222228,0.001163106],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.8029916,"threshold_uncertainty_score":0.9902316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2707149978191177,"score_gpt":0.477529410803239,"score_spread":0.2068144129841213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}