{"id":"W2997351648","doi":"10.1200/jco.19.01381","title":"Phase III Study of Adjuvant Ipilimumab (3 or 10 mg/kg) Versus High-Dose Interferon Alfa-2b for Resected High-Risk Melanoma: North American Intergroup E1609","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Medicine; Ipilimumab; Discontinuation; Adverse effect; Internal medicine; Hazard ratio; Melanoma; Adjuvant; Cancer; Gastroenterology; Phases of clinical research; Oncology; Clinical trial; Surgery; Confidence interval; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001924259,0.0002882134,0.002802189,0.0003958189,0.00005690279,0.00001351426,0.0003734262,0.0002053641,0.0008657285],"category_scores_gemma":[0.002884975,0.0001967703,0.0005478544,0.0003757323,0.0002112112,0.0001000591,0.0001928419,0.001084492,0.00005217606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003628574,"about_ca_system_score_gemma":0.0005522617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004933681,"about_ca_topic_score_gemma":0.005340248,"domain_scores_codex":[0.9945805,0.0006236424,0.003446538,0.0004378748,0.0005268017,0.0003846598],"domain_scores_gemma":[0.9915392,0.002980163,0.003772203,0.0005390801,0.0007298141,0.0004394794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.57117,0.02264746,0.008788956,0.00008286562,0.002988671,0.00108384,0.0005201195,0.00003131087,0.0004448292,0.00001851516,0.006769174,0.3854542],"study_design_scores_gemma":[0.2228553,0.6587011,0.05850106,0.00009404041,0.002265546,0.0002464554,0.003552198,0.0004851735,0.0001549456,0.00002020493,0.05286876,0.0002552768],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914979,0.00004030747,0.0002734708,0.0008194627,0.005542998,0.0014533,0.00002297345,0.00003169942,0.0003178494],"genre_scores_gemma":[0.9950069,0.0002184006,0.001214167,0.000338058,0.001058285,0.00002372042,0.00001572294,0.00004418792,0.002080556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6360536,"threshold_uncertainty_score":0.947912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07986884141034623,"score_gpt":0.4345343013265612,"score_spread":0.354665459916215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}