{"id":"W2997361961","doi":"10.3233/kca-190077","title":"Individualization of Dose and Schedule Based On Toxicity for Oral VEGF Drugs in Kidney Cancer","year":2019,"lang":"en","type":"article","venue":"Kidney Cancer","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Dosing; Medicine; Toxicity; Vascular endothelial growth factor; Cancer; Drug; Tyrosine-kinase inhibitor; Adjuvant; Oncology; VEGF receptors; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001896546,0.0002309802,0.0007935317,0.0004028572,0.0001874647,0.0005735988,0.000440646,0.0002590617,0.000547788],"category_scores_gemma":[0.002089405,0.0001034633,0.0005894874,0.0003167837,0.0002139712,0.0003816623,0.0002363034,0.0006662716,0.0001572282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009218244,"about_ca_system_score_gemma":0.0005554296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003261776,"about_ca_topic_score_gemma":0.001249418,"domain_scores_codex":[0.999212,0.0003940996,0.0001074608,0.00005682217,0.0001939374,0.00003567702],"domain_scores_gemma":[0.9990773,0.0004511634,0.0003518265,0.00003093503,0.00005612691,0.00003267603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002120043,0.0003987398,0.004720559,0.002601245,0.0002881874,0.0001927118,0.0001334896,0.006447165,0.01235565,0.001587671,0.003108814,0.9660457],"study_design_scores_gemma":[0.004847916,0.05125666,0.1393866,0.005877248,0.003357441,0.01177386,0.0005468262,0.01667211,0.06305546,0.01454901,0.6883451,0.0003318196],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2019039,0.7505059,0.02483791,0.006181257,0.0007520215,0.0004895915,0.0001661536,0.0001981968,0.01496512],"genre_scores_gemma":[0.6227665,0.3450082,0.02489482,0.00198287,0.001565359,0.0003509006,0.00020932,0.0001187986,0.003103311],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001896546,"threshold_uncertainty_score":0.01003003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0229485505792703,"score_gpt":0.3077115109704465,"score_spread":0.2847629603911762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}