{"id":"W2997375218","doi":"10.1016/j.ijbiomac.2019.12.236","title":"Thermal aggregates of human mortalin and Hsp70-1A behave as supramolecular assemblies","year":2019,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Hsp70; Biogenesis; Chaperone (clinical); Heat shock protein; Cell biology; Mitochondrion; Chemistry; Biophysics; Recombinant DNA; Protein folding; Supramolecular chemistry; Cytosol; Biochemistry; Biology; Gene; Crystallography; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001202229,0.000209555,0.0001587259,0.0002005851,0.0002502271,0.000284249,0.0001589512,0.0002147798,0.001147715],"category_scores_gemma":[0.0002548878,0.0001871716,0.0002212305,0.0001027214,0.0002710158,0.0003719461,0.0002282635,0.0004685975,0.0003283851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002262253,"about_ca_system_score_gemma":0.00007981887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001629936,"about_ca_topic_score_gemma":0.0001701402,"domain_scores_codex":[0.9998894,0.00001875503,0.000006566147,0.00002783153,0.00002520638,0.00003229192],"domain_scores_gemma":[0.9998375,0.00002834996,0.00005346601,0.00001799156,0.00001892521,0.00004364776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001677022,0.00003655676,0.0008947533,0.00002193494,0.00001680648,0.0000668217,0.00005237478,0.0003560311,0.9973294,0.0002673661,0.00009035519,0.00069994],"study_design_scores_gemma":[0.00003951782,0.0003850505,0.02055887,0.000008703228,0.00003566346,0.0003339218,0.0001887927,0.00563902,0.9711585,0.0003290444,0.001301879,0.00002111753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978126,0.0002728072,0.00110344,0.00003774389,0.00002173514,0.00000945874,0.00004111253,0.00003716075,0.0006638542],"genre_scores_gemma":[0.9989597,0.00005882658,0.000303255,0.00003656065,0.000006375302,0.000009063119,0.00007821617,0.000008357382,0.0005397021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001147715,"threshold_uncertainty_score":0.003839493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01822653246953821,"score_gpt":0.3261135271940715,"score_spread":0.3078869947245333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}