{"id":"W2997404094","doi":"10.1084/jem.20191043","title":"Syk degradation restrains plasma cell formation and promotes zonal transitions in germinal centers","year":2019,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Benoziyo Endowment Fund for the Advancement of Science; Rising Tide Foundation; Azrieli Foundation; Irma und Jacques Ber-Lehmsdorf - Stiftung; Israel Science Foundation; European Research Council; German-Israeli Foundation for Scientific Research and Development; Gerald O. Mann Charitable Foundation; European Molecular Biology Organization","keywords":"Syk; Cell biology; breakpoint cluster region; Germinal center; Signal transduction; MAPK/ERK pathway; Cell fate determination; B-cell receptor; B cell; Biology; Cell; Chemistry; Transcription factor; Receptor; Tyrosine kinase; Gene; Antibody; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009512157,0.0002280139,0.0002199437,0.0002253446,0.0001529126,0.0003165661,0.0001343549,0.0001785786,0.0008435384],"category_scores_gemma":[0.00007590664,0.0001393672,0.000184454,0.00008852204,0.0002699137,0.000187047,0.0002273772,0.0005330152,0.0002682843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349731,"about_ca_system_score_gemma":0.0002222307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004728404,"about_ca_topic_score_gemma":0.0007646212,"domain_scores_codex":[0.9998921,0.00001253224,0.00001016746,0.00002650284,0.0000204492,0.00003818742],"domain_scores_gemma":[0.9998872,0.000008279853,0.00003545849,0.00001236991,0.000008510532,0.00004822354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001140071,0.00001799217,0.0001884672,0.00002222208,0.000003067617,0.00002284411,0.00001055484,0.00003050224,0.998886,0.00007266176,0.00002314759,0.0006084843],"study_design_scores_gemma":[0.00001791785,0.0001788109,0.008054527,0.000004483498,0.00001157868,0.0001310737,0.00003120592,0.0005577877,0.9898903,0.00004996761,0.001069131,0.00000320558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974648,0.000895191,0.0009104878,0.00004683295,0.00001476444,0.000006662081,0.0001219311,0.00006374381,0.0004756156],"genre_scores_gemma":[0.9979164,0.0003493384,0.0004565681,0.00002275997,0.000005241723,0.000009643882,0.000155072,0.00001405615,0.001070935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008435384,"threshold_uncertainty_score":0.002821863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317992640657424,"score_gpt":0.2439765537974708,"score_spread":0.2307966273908966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}