{"id":"W2997404448","doi":"10.1016/j.toxicon.2019.12.154","title":"The effects of Hemiscorpius lepturus induced-acute kidney injury on PGC-1α gene expression: From induction to suppression in mice","year":2019,"lang":"en","type":"article","venue":"Toxicon","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Zanjan University of Medical Sciences","keywords":"Reactive oxygen species; Acute kidney injury; Homeostasis; Mitochondrion; Pharmacology; Downregulation and upregulation; Biology; Kidney; Mitochondrial ROS; Envenomation; Glutathione; Cell biology; Medicine; Biochemistry; Internal medicine; Endocrinology; Enzyme; Venom; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001979066,0.0007197785,0.0003092368,0.0007097157,0.0003471695,0.0003048173,0.0003042148,0.0005955878,0.002273571],"category_scores_gemma":[0.00009961749,0.0002905839,0.0006202881,0.0002769523,0.0007897245,0.000421273,0.0002858895,0.001355865,0.0003043213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003779272,"about_ca_system_score_gemma":0.0004173052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013478,"about_ca_topic_score_gemma":0.001934833,"domain_scores_codex":[0.9997852,0.00001882137,0.00002042229,0.00006029967,0.00004273168,0.00007251649],"domain_scores_gemma":[0.9997829,0.00001105565,0.00007272526,0.0000235446,0.00001428602,0.00009553303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001213729,0.0001892132,0.0005066041,0.00004771546,0.00001176804,0.0001231202,0.00006168972,0.00007796117,0.9963897,0.0001835728,0.0000607439,0.001134222],"study_design_scores_gemma":[0.0001411205,0.002377514,0.01259362,0.00002133728,0.00008295997,0.0003030576,0.0001927013,0.0005182353,0.9817041,0.0001564536,0.001891266,0.00001769935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962448,0.0005944581,0.001277986,0.0001784579,0.00004715127,0.00004560823,0.0005673135,0.00008630516,0.0009578224],"genre_scores_gemma":[0.9856843,0.0009856607,0.001260607,0.0002013803,0.0000212643,0.0001697272,0.0008413914,0.00004482679,0.01079084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002273571,"threshold_uncertainty_score":0.007605791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006361585169683233,"score_gpt":0.2435983051165321,"score_spread":0.2372367199468489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}