{"id":"W2997409943","doi":"10.1016/j.xphs.2019.12.020","title":"Efficiency of Chitosan/Hyaluronan-Based mRNA Delivery Systems In Vitro: Influence of Composition and Structure","year":2019,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"","keywords":"Chemistry; Sulfation; Transfection; Trehalose; In vitro; Chitosan; Nucleic acid; Biochemistry; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002589103,0.00007645899,0.0001849456,0.00009906548,0.00002173585,0.0000134028,0.0002294643,0.00005957658,0.00000635786],"category_scores_gemma":[0.00002722018,0.0000560254,0.00005069683,0.0001507791,0.0002613081,0.00001638632,0.00003686881,0.0001014166,2.766872e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004792309,"about_ca_system_score_gemma":0.0001123452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000198536,"about_ca_topic_score_gemma":7.296071e-7,"domain_scores_codex":[0.9990497,0.00007140122,0.0003612793,0.0001291013,0.0002577146,0.0001307945],"domain_scores_gemma":[0.9995083,0.00003823193,0.0002473452,0.00006434435,0.00008269714,0.00005905526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000204904,0.00005054278,0.02017892,0.00005518738,0.000009106781,0.000001815967,0.00002141213,0.01462287,0.9640083,0.00001216611,0.000002679616,0.0008321441],"study_design_scores_gemma":[0.0005144246,0.000761945,0.01168309,0.0001033474,0.00001305028,0.00002640822,0.00007449742,0.004610251,0.9821059,0.000007994078,0.00003449459,0.00006467258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977686,0.001840446,0.00005009801,0.00004684649,0.0001370341,0.00007820008,0.00001142742,6.395082e-7,0.00006664726],"genre_scores_gemma":[0.9996132,0.000111376,0.0001660788,0.00007187539,0.00003265151,3.090131e-7,0.000001180186,0.000002218733,0.00000113314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01809757,"threshold_uncertainty_score":0.228465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218169385506731,"score_gpt":0.2957157351013154,"score_spread":0.2835340412462481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}