{"id":"W2997409943","doi":"10.1016/j.xphs.2019.12.020","title":"Efficiency of Chitosan/Hyaluronan-Based mRNA Delivery Systems In Vitro: Influence of Composition and Structure","year":2019,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"","keywords":"Chemistry; Sulfation; Transfection; Trehalose; In vitro; Chitosan; Nucleic acid; Biochemistry; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008111854,0.0005066695,0.0004249908,0.0003253201,0.000318817,0.0006463206,0.0002872071,0.0003932548,0.0007602079],"category_scores_gemma":[0.0006545719,0.0002828171,0.0003634631,0.0003177323,0.0003439816,0.0004450461,0.0002307103,0.0004510081,0.0003041177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007901019,"about_ca_system_score_gemma":0.000595895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002370555,"about_ca_topic_score_gemma":0.002440981,"domain_scores_codex":[0.9994747,0.0001533587,0.00006989938,0.00007674105,0.0001333132,0.00009197901],"domain_scores_gemma":[0.9994195,0.0002876331,0.00009552199,0.00003497508,0.0001099719,0.00005242736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001396179,0.000019619,0.00005910436,0.00004775688,0.000008835601,0.00001331868,0.00003457932,0.0001067945,0.9983509,0.00005332525,0.00001651248,0.001149761],"study_design_scores_gemma":[0.00000249677,0.00007415445,0.000215156,0.000001548746,0.00001032878,0.000007476254,0.000004217631,0.0002098487,0.9993117,0.000004462023,0.0001558917,0.000002656771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913975,0.002464156,0.004076853,0.00004676294,0.00003162773,0.000045664,0.0002504971,0.00006710696,0.001619794],"genre_scores_gemma":[0.992835,0.0009445315,0.003312672,0.00002552005,0.00001061448,0.00003690044,0.000324835,0.00004283311,0.002466943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002370555,"threshold_uncertainty_score":0.005732656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218169385506731,"score_gpt":0.2957157351013154,"score_spread":0.2835340412462481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}