{"id":"W2997460958","doi":"10.1002/jgc4.1198","title":"Somatic mismatch repair testing in evaluation of Lynch syndrome: The gap between preferred and current practices","year":2020,"lang":"en","type":"article","venue":"Journal of Genetic Counseling","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Lynch syndrome; MSH6; PMS2; Genetic testing; MSH2; Medicine; Genetic counseling; MLH1; Germline mutation; DNA mismatch repair; Oncology; Cancer; Family medicine; Genetics; Gynecology; Internal medicine; Colorectal cancer; Mutation; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002398762,0.0001212479,0.0003878855,0.00009215689,0.00003866195,0.00001969158,0.0001198402,0.0000532703,0.00002907539],"category_scores_gemma":[0.004607828,0.0000860681,0.0000719181,0.0003298776,0.00005020197,0.00005935984,0.00003053717,0.0003634738,0.000001068724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009673017,"about_ca_system_score_gemma":0.0005611985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001512475,"about_ca_topic_score_gemma":0.000006359811,"domain_scores_codex":[0.9975036,0.0002462987,0.0008922024,0.0001560258,0.001051635,0.0001501909],"domain_scores_gemma":[0.9969718,0.0007774858,0.001259292,0.0001499504,0.0007314948,0.0001099927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003096047,0.0001665569,0.7906264,0.00169406,0.0003395045,0.00005906169,0.01354534,0.008061687,0.03206015,5.485009e-7,0.0002657502,0.1528713],"study_design_scores_gemma":[0.002872363,0.001680645,0.8791634,0.002074728,0.001774751,0.0009720554,0.001921903,0.1069057,0.001646781,0.0004864248,0.0003199132,0.0001813135],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816322,0.01647502,0.0001949924,0.001012761,0.0001805419,0.0004510793,0.000001590632,0.000008391925,0.00004343799],"genre_scores_gemma":[0.9931208,0.0005024765,0.006090058,0.00005428695,0.0002084844,0.000006490637,5.87991e-7,0.0000152739,0.000001469724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.15269,"threshold_uncertainty_score":0.5516334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2044881865000954,"score_gpt":0.3825549579452363,"score_spread":0.1780667714451409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}