{"id":"W2997476486","doi":"10.1182/bloodadvances.2019000488","title":"Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells","year":2020,"lang":"en","type":"article","venue":"Blood Advances","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Cancer Institute; National Institute of General Medical Sciences; Cancer Research UK; European Hematology Association","keywords":"Myeloid; Langerhans cell histiocytosis; Biology; Dendritic cell; Lesion; Immunology; Bone marrow; Langerin; Antigen; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007111503,0.0001258722,0.0001954224,0.0004546766,0.0001872714,0.0002997078,0.00006302038,0.0001628289,0.002468174],"category_scores_gemma":[0.000187757,0.00008724563,0.00008958882,0.0002872723,0.00009570205,0.0001027236,0.0001486717,0.0002135823,0.0006475433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000145045,"about_ca_system_score_gemma":0.0001002514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003263147,"about_ca_topic_score_gemma":0.0004273943,"domain_scores_codex":[0.9999024,0.00000943643,0.000006080474,0.00003352941,0.00002077166,0.00002780422],"domain_scores_gemma":[0.9999263,0.00001361549,0.00001917006,0.000006897214,0.00001351887,0.0000204901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005864214,0.00003964661,0.02028533,0.00009626747,0.000008357496,0.0003177474,0.0001863876,0.00004478399,0.96938,0.0001540158,0.000202666,0.008698518],"study_design_scores_gemma":[0.00006407254,0.0007888735,0.5708865,0.00007268212,0.00008736473,0.004658217,0.000911542,0.001843133,0.4039006,0.000555131,0.01620763,0.00002437787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954323,0.001105229,0.000944632,0.00003469868,0.000007937075,0.00004827396,0.0009971242,0.00004572566,0.001384221],"genre_scores_gemma":[0.9951592,0.0005624458,0.001509418,0.00004713682,0.00002497206,0.0000622542,0.001294626,0.00001493591,0.001325177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002468174,"threshold_uncertainty_score":0.008256853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01671060837169836,"score_gpt":0.2591382869210894,"score_spread":0.2424276785493911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}