{"id":"W2997569907","doi":"10.1200/jco.19.02456","title":"Ethical and Policy Issues for Seamless Phase I Oncology Trials","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Oncology; Phase (matter); Internal medicine; Family medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.4676583,0.0007388632,0.002597896,0.001771035,0.008212315,0.02484028,0.008684877,0.0739671,0.01050817],"category_scores_gemma":[0.5224517,0.002576327,0.00400377,0.002493356,0.02468371,0.01286899,0.01135161,0.05959083,0.004413906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005100626,"about_ca_system_score_gemma":0.05441887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001943411,"about_ca_topic_score_gemma":0.003506418,"domain_scores_codex":[0.602153,0.3076107,0.02509492,0.01390362,0.03964454,0.01159319],"domain_scores_gemma":[0.3085746,0.5671305,0.02253968,0.0482553,0.02641764,0.02708215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001588495,0.0007064974,0.003579,0.001089908,0.0003286797,0.001649639,0.00646935,0.002034117,0.001413703,0.5787931,0.2941365,0.108211],"study_design_scores_gemma":[0.001791172,0.001149546,0.004697538,0.005342652,0.0003543959,0.004569566,0.005523365,0.004831656,0.001783797,0.4407449,0.5289156,0.0002957854],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.006514592,0.007648116,0.0329267,0.8942689,0.01506212,0.001971176,0.0002747914,0.0002588958,0.04107464],"genre_scores_gemma":[0.1235531,0.002339259,0.07208437,0.7727585,0.01227771,0.00675951,0.0002828302,0.0002634199,0.009681139],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9260329,"threshold_uncertainty_score":0.6564721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1810430607852295,"score_gpt":0.5865204832438125,"score_spread":0.4054774224585829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}