{"id":"W2997733976","doi":"10.1371/journal.pone.0226593","title":"Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Antibody-drug conjugate; Avidity; Antibody; Internalization; Flow cytometry; Chemistry; Cytotoxicity; Conjugate; Molecular biology; Monoclonal antibody; In vitro; Cancer research; Cell; Biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000467049,0.0005195066,0.0004506831,0.0003117494,0.0001310272,0.0004579262,0.0003142513,0.0003327004,0.0007423349],"category_scores_gemma":[0.0005259078,0.0002105517,0.0002108233,0.0002699106,0.0001556783,0.000196625,0.0002272528,0.0004481829,0.0003247673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000397777,"about_ca_system_score_gemma":0.0002312199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006673501,"about_ca_topic_score_gemma":0.001707842,"domain_scores_codex":[0.999674,0.00006628027,0.00003765409,0.00005419666,0.0001086802,0.00005920804],"domain_scores_gemma":[0.9998061,0.00004814546,0.00004674137,0.00002130281,0.00005352816,0.00002428486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005013773,0.00003994238,0.0005308777,0.00001844719,0.000005424214,0.00002823412,0.00001435447,0.001071009,0.9962231,0.00007407551,0.00002536806,0.001918924],"study_design_scores_gemma":[0.000008199722,0.0003202306,0.001904209,0.000003157587,0.0000159032,0.00009910766,0.00002070339,0.003355981,0.9933734,0.00002916548,0.0008642185,0.000005819001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842311,0.0005156873,0.01335659,0.00005293086,0.00000611063,0.0001844398,0.0003903348,0.00008194621,0.001180897],"genre_scores_gemma":[0.9803514,0.0005204394,0.01718059,0.00004265904,0.000003142432,0.00008920097,0.0005291731,0.00003739103,0.001246022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007423349,"threshold_uncertainty_score":0.002886057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03444517121429226,"score_gpt":0.3075947744815976,"score_spread":0.2731496032673054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}