{"id":"W2997764258","doi":"10.1084/jem.20181657","title":"Cartilage-binding antibodies induce pain through immune complex–mediated activation of neurons","year":2019,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Kungliga Fysiografiska Sällskapet i Lund; Alfred Österlunds Stiftelse; Government of Guangdong Province; Stiftelsen för Strategisk Forskning; Vetenskapsrådet; Cancer Research UK; Karolinska Institutet; Åke Wiberg Stiftelse; University of Pittsburgh; Torsten Söderbergs Stiftelse; University of California, San Diego; Knut och Alice Wallenbergs Stiftelse; Ragnar Söderbergs stiftelse; Canada Excellence Research Chairs, Government of Canada","keywords":"Autoantibody; Antibody; Immune system; Cartilage; Inflammation; Cartilage oligomeric matrix protein; Immunology; Medicine; Nociception; Arthritis; Immune complex; Cell biology; Chemistry; Pathology; Molecular biology; Biology; Anatomy; Osteoarthritis; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001969156,0.0004314908,0.0001926679,0.0002828487,0.0001072674,0.0002052802,0.0002286383,0.0003492847,0.001575146],"category_scores_gemma":[0.0001423967,0.0001353461,0.0003304459,0.00007971465,0.0002596336,0.0001901823,0.0002187335,0.0006728615,0.00027601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003086054,"about_ca_system_score_gemma":0.0001616725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004811795,"about_ca_topic_score_gemma":0.0008365274,"domain_scores_codex":[0.9997684,0.00003400719,0.00002029139,0.00004140193,0.00005569942,0.00008026027],"domain_scores_gemma":[0.9998966,0.00002269964,0.00002769693,0.00001397986,0.00001375904,0.00002529545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000486383,0.00001676887,0.00006832456,0.00002848479,0.000002852289,0.00002456114,0.000005547645,0.00001317975,0.9992113,0.00004774333,0.00001378102,0.0005188535],"study_design_scores_gemma":[0.00003730194,0.001058556,0.006875052,0.00001772663,0.00002271989,0.0003634435,0.00002927098,0.0005887928,0.9902173,0.00007944743,0.0007072603,0.000003177582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915184,0.001542688,0.003313525,0.00009824839,0.00004542091,0.00003646962,0.0001443494,0.00007782976,0.003223088],"genre_scores_gemma":[0.9944761,0.0007419126,0.00198542,0.00009865966,0.00002149098,0.00004152272,0.0001479325,0.00001245773,0.002474469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001575146,"threshold_uncertainty_score":0.005269349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06416095221067875,"score_gpt":0.359180768188801,"score_spread":0.2950198159781223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}