{"id":"W2997782929","doi":"10.3390/cells9010100","title":"Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction","year":2019,"lang":"en","type":"review","venue":"Cells","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Hebrew University of Jerusalem; Universidade de Macau; National Natural Science Foundation of China","keywords":"Calorie restriction; Transcription factor; Biology; Forkhead Transcription Factors; AMPK; FOXO1; PI3K/AKT/mTOR pathway; Longevity; Sterol regulatory element-binding protein; Cell biology; Energy homeostasis; Cellular stress response; Signal transduction; FOXO3; Cell fate determination; TOR signaling; Protein kinase B; Protein kinase A; Genetics; Kinase; Gene; Fight-or-flight response; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000205334,0.0002892757,0.0009123524,0.00008150678,0.00001967095,0.000006402858,0.0002427224,0.0005171531,0.000007786985],"category_scores_gemma":[0.00001110801,0.0002710621,0.0004105895,0.0001650674,0.00005115364,0.000002832703,0.00004414371,0.0001930347,0.000004491957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002573749,"about_ca_system_score_gemma":0.0001393905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007800096,"about_ca_topic_score_gemma":0.00001765187,"domain_scores_codex":[0.9984481,0.0001130853,0.0006797991,0.0003656733,0.0001469237,0.0002464697],"domain_scores_gemma":[0.9990735,0.00002790056,0.0003935152,0.0004038403,0.00005971123,0.00004150996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007626552,0.0004157825,0.0007095126,0.04529462,0.000572425,0.000004482115,0.0006830106,0.01233486,0.6836933,0.00004628818,0.002136091,0.2540333],"study_design_scores_gemma":[0.0008066979,0.001182082,0.000516452,0.008726898,0.001608657,0.000003191253,0.0001556701,0.00009271231,0.09168066,0.000203357,0.8937053,0.00131833],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03367047,0.9629028,0.001979259,0.000001116908,0.0007462758,0.0004948825,0.00005877971,0.000005127414,0.0001412343],"genre_scores_gemma":[0.04529183,0.9534709,0.0004150392,0.00001020989,0.0001914705,0.000007039495,0.0004639483,0.00004611975,0.0001034374],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8915692,"threshold_uncertainty_score":0.9999741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06659701300273466,"score_gpt":0.2896326901043679,"score_spread":0.2230356771016332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}