{"id":"W2997782929","doi":"10.3390/cells9010100","title":"Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction","year":2019,"lang":"en","type":"review","venue":"Cells","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Hebrew University of Jerusalem; Universidade de Macau; National Natural Science Foundation of China","keywords":"Calorie restriction; Transcription factor; Biology; Forkhead Transcription Factors; AMPK; FOXO1; PI3K/AKT/mTOR pathway; Longevity; Sterol regulatory element-binding protein; Cell biology; Energy homeostasis; Cellular stress response; Signal transduction; FOXO3; Cell fate determination; TOR signaling; Protein kinase B; Protein kinase A; Genetics; Kinase; Gene; Fight-or-flight response; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003701949,0.0007043271,0.0008035942,0.001242268,0.0002802607,0.0007818509,0.0006850858,0.0009353578,0.00222217],"category_scores_gemma":[0.0003731172,0.0002268802,0.0003250383,0.001392554,0.0003853615,0.001002906,0.00061213,0.001389734,0.00122361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006461137,"about_ca_system_score_gemma":0.0009889276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008656089,"about_ca_topic_score_gemma":0.001204862,"domain_scores_codex":[0.9999011,0.0000163619,0.00001462157,0.00002530343,0.0000301754,0.00001250711],"domain_scores_gemma":[0.9998889,0.00003886623,0.0000189979,0.00000340057,0.00003467149,0.00001523961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000120036,0.00006724579,0.0002091573,0.01814286,0.00009623057,0.0002374395,0.00009376056,0.0006968016,0.004658232,0.008315071,0.03423185,0.9331313],"study_design_scores_gemma":[0.000012955,0.00007353472,0.0005995142,0.001726136,0.00006755362,0.0005453366,0.00004169465,0.00008796372,0.0006678134,0.00201132,0.9941528,0.00001336979],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002064173,0.9977493,0.0002366304,0.0003503214,0.0003180331,0.000005041523,0.00002659628,0.00001359136,0.001094073],"genre_scores_gemma":[0.0008040593,0.9980806,0.0001688631,0.0001603134,0.0001096682,0.000007919714,0.00003370551,0.000001654935,0.0006331785],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00222217,"threshold_uncertainty_score":0.007433951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06659701300273466,"score_gpt":0.2896326901043679,"score_spread":0.2230356771016332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}