{"id":"W2997853549","doi":"10.3390/v12010065","title":"H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice","year":2020,"lang":"en","type":"article","venue":"Viruses","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Canadian Food Inspection Agency; University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"Virulence; Influenza A virus subtype H5N1; Biology; Virus; Virology; Host adaptation; Phenotype; Reverse genetics; Influenza A virus; Hemagglutinin (influenza); Host (biology); Microbiology; Gene; Genetics; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004364205,0.0007475081,0.0004104618,0.0005403465,0.0002455242,0.0005482443,0.0006292352,0.001025471,0.001722676],"category_scores_gemma":[0.0002248321,0.0004158449,0.0005472844,0.0001871916,0.0004801441,0.0003650951,0.0003611004,0.001928114,0.0008686864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004868035,"about_ca_system_score_gemma":0.0003500019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008691107,"about_ca_topic_score_gemma":0.001458789,"domain_scores_codex":[0.9993338,0.000127413,0.00007630217,0.000140487,0.0001638001,0.0001582725],"domain_scores_gemma":[0.9996152,0.00007153757,0.0001068782,0.00006122347,0.0000297956,0.0001153201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001175412,0.0001085421,0.0001568566,0.00001985847,0.000006748878,0.00004599441,0.00001746074,0.00005756385,0.9987795,0.0001553278,0.00003245442,0.000502156],"study_design_scores_gemma":[0.00009266695,0.001368293,0.005848778,0.00002824396,0.00002935854,0.0007524332,0.00005742447,0.002164338,0.9860934,0.0001295263,0.003418783,0.00001669672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872884,0.0008785055,0.006778353,0.000219253,0.00006948441,0.0002076028,0.001146347,0.0002310885,0.003181022],"genre_scores_gemma":[0.9825264,0.0008995851,0.008728287,0.0002177071,0.00002830752,0.0002982709,0.001835851,0.0001328253,0.005332703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001722676,"threshold_uncertainty_score":0.005762875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1257593595746315,"score_gpt":0.3643328172791397,"score_spread":0.2385734577045082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}