{"id":"W2997855080","doi":"10.1002/jcsm.12517","title":"Longitudinal serum biomarker screening identifies malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophy","year":2019,"lang":"en","type":"article","venue":"Journal of Cachexia Sarcopenia and Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Medical Research Council; Duchenne Parent Project; European Commission; National Institute for Health and Care Research; NIHR Great Ormond Street Hospital Biomedical Research Centre; Science for Life Laboratory; French Muscular Dystrophy Association","keywords":"Medicine; Duchenne muscular dystrophy; Biomarker; Internal medicine; Clinical trial; Disease; Oncology; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001249247,0.0003427375,0.0004565976,0.0005339608,0.000219535,0.0005400247,0.0002449139,0.0003868105,0.0007251647],"category_scores_gemma":[0.001952693,0.0001415482,0.0003330326,0.0006284682,0.0001842903,0.000216431,0.0002912937,0.0004261209,0.0001628226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003266316,"about_ca_system_score_gemma":0.0003294751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208314,"about_ca_topic_score_gemma":0.001692517,"domain_scores_codex":[0.9996966,0.0001207266,0.00002926686,0.00007164104,0.00003906759,0.00004268952],"domain_scores_gemma":[0.9984834,0.0004277022,0.0006442227,0.00006450806,0.0001826344,0.0001976916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005783817,0.00005884202,0.9926189,0.00001526669,0.00005288223,0.00007369385,0.00003285935,0.0001335182,0.003837602,0.000008113559,0.00007368655,0.002516303],"study_design_scores_gemma":[0.00002015629,0.0005771595,0.994841,0.000008032098,0.0000902853,0.0003298933,0.00007464043,0.002070305,0.001763595,0.00003279451,0.0001868874,0.000005258533],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999188,0.0003320671,0.0002705139,0.00003805463,0.000003553442,0.000004844877,0.00008698539,0.000006771428,0.00006923324],"genre_scores_gemma":[0.9993218,0.00006583585,0.0003597224,0.00001820855,0.000005296261,0.000005682687,0.0001540994,0.00000101329,0.00006838759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001249247,"threshold_uncertainty_score":0.006606758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308277478439568,"score_gpt":0.2653633923673514,"score_spread":0.2522806175829557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}