{"id":"W2997855080","doi":"10.1002/jcsm.12517","title":"Longitudinal serum biomarker screening identifies malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophy","year":2019,"lang":"en","type":"article","venue":"Journal of Cachexia Sarcopenia and Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Medical Research Council; Duchenne Parent Project; European Commission; National Institute for Health and Care Research; NIHR Great Ormond Street Hospital Biomedical Research Centre; Science for Life Laboratory; French Muscular Dystrophy Association","keywords":"Medicine; Duchenne muscular dystrophy; Biomarker; Internal medicine; Clinical trial; Disease; Oncology; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004759192,0.000253733,0.0003604786,0.0001236682,0.000151176,0.00007114964,0.0002359393,0.0001852372,0.000104886],"category_scores_gemma":[0.000144982,0.0002159125,0.0002829615,0.0001109003,0.0001286426,0.00004219759,0.0001306069,0.0001389235,0.00001287787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001097655,"about_ca_system_score_gemma":0.0001176778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003669186,"about_ca_topic_score_gemma":0.00002430721,"domain_scores_codex":[0.9985178,0.00009543762,0.0004460642,0.0003721782,0.0001763479,0.0003922008],"domain_scores_gemma":[0.9989172,0.00004592796,0.0003295856,0.0002754868,0.000233366,0.0001984948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001763918,0.0001107825,0.02907342,0.0001450357,0.0005702662,0.00003694253,0.00005898496,0.00008278274,0.9587715,0.00003878079,0.001154003,0.008193579],"study_design_scores_gemma":[0.00935168,0.002416965,0.8362895,0.0002665462,0.0006126109,0.0005595548,0.0004706854,0.0007327737,0.1001621,0.0008848035,0.04726572,0.0009870492],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950308,0.002898488,0.0008655866,0.0002930764,0.0003013162,0.0004113737,0.00003285733,0.00000701443,0.0001595194],"genre_scores_gemma":[0.9982603,0.0002569515,0.0007146353,0.0001957271,0.0001299261,0.00001608863,0.0000519447,0.0000369579,0.0003374516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8586094,"threshold_uncertainty_score":0.8804655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308277478439568,"score_gpt":0.2653633923673514,"score_spread":0.2522806175829557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}