{"id":"W2997860055","doi":"10.1074/mcp.ra119.001858","title":"Peptidomic Analysis of Urine from Youths with Early Type 1 Diabetes Reveals Novel Bioactivity of Uromodulin Peptides In Vitro","year":2019,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University Health Network; University of Toronto; Toronto General Hospital; Toronto Rehabilitation Institute","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research; Diabetes Canada; Juvenile Diabetes Research Foundation Canada; Heart and Stroke Foundation of Canada","keywords":"Tamm–Horsfall protein; Proteases; Diabetic nephropathy; Diabetes mellitus; Kidney; Chemistry; Peptide; Type 2 diabetes; Urinary system; Biology; Endocrinology; Internal medicine; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004022725,0.0003540371,0.0008661837,0.0003344116,0.00002425449,0.00002193911,0.0003965928,0.0002542181,0.00002477621],"category_scores_gemma":[0.00008158218,0.0003179593,0.0003622352,0.0008413264,0.0001761396,0.00001497126,0.0002036048,0.0001945973,0.000005448052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003540828,"about_ca_system_score_gemma":0.00008922394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005503363,"about_ca_topic_score_gemma":0.00004761512,"domain_scores_codex":[0.9978488,0.0001532347,0.0005635994,0.0007355529,0.0003237557,0.0003750337],"domain_scores_gemma":[0.9982327,0.00002724763,0.0005063221,0.0009272516,0.0002196363,0.00008679476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007523419,0.0003169343,0.05240067,0.00005081611,0.001417094,0.000004786188,0.00006876623,0.001337508,0.9434928,0.00001886938,8.130125e-7,0.0001385659],"study_design_scores_gemma":[0.001097926,0.0005352824,0.02347991,0.00005208331,0.0004932202,5.037143e-7,0.00003498619,0.001301958,0.9725723,0.0000560688,0.0000157712,0.0003599898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940192,0.0005956141,0.004121608,0.00002253193,0.00003259166,0.0008483063,0.0002585245,0.000009065297,0.0000925351],"genre_scores_gemma":[0.9897333,0.00003083801,0.009497475,0.00003486642,0.00003035563,0.00003723948,0.000514634,0.00005113217,0.00007010635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02907947,"threshold_uncertainty_score":0.9999272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005509393600965453,"score_gpt":0.1980355962944597,"score_spread":0.1925262026934942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}