{"id":"W2997876124","doi":"10.1186/s13008-019-0058-4","title":"The essentiality landscape of cell cycle related genes in human pluripotent and cancer cells","year":2019,"lang":"en","type":"article","venue":"Cell Division","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; United States-Israel Binational Science Foundation; Hebrew University of Jerusalem; Rosetrees Trust","keywords":"Biology; Cell cycle; Induced pluripotent stem cell; Carcinogenesis; Embryonic stem cell; Gene; Cell growth; Cell biology; Cancer cell; CRISPR; Cell cycle checkpoint; Genetics; Cell division; Cell; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039716,0.000125778,0.0001392631,0.0004423819,0.0001308993,0.0002299088,0.00008780047,0.0001223819,0.001035839],"category_scores_gemma":[0.0002053734,0.00007208491,0.0001445129,0.0003264162,0.0001062473,0.0001071354,0.0001507592,0.000150407,0.0002083387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001654717,"about_ca_system_score_gemma":0.0001822771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000459694,"about_ca_topic_score_gemma":0.00053046,"domain_scores_codex":[0.9998997,0.00001109925,0.00001094284,0.00003322711,0.00002997088,0.0000149846],"domain_scores_gemma":[0.9998558,0.00004080835,0.0000423548,0.00001847068,0.00002280553,0.00001987884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008551114,0.000006958941,0.004251365,0.00005152962,0.000009228485,0.00008435272,0.00001596255,0.00030887,0.9905127,0.0002383044,0.00006118996,0.00437408],"study_design_scores_gemma":[0.00001497805,0.000224139,0.1421933,0.00001788246,0.00009136843,0.00107911,0.00008994907,0.00609299,0.8407958,0.0006723296,0.008711789,0.00001635076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919487,0.001260759,0.004162511,0.00003513838,0.000007762698,0.00001581431,0.001639049,0.00007677401,0.0008534389],"genre_scores_gemma":[0.9929798,0.0004378669,0.003076856,0.00004774179,0.00000415492,0.00002223802,0.002805771,0.00002629027,0.0005992927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001035839,"threshold_uncertainty_score":0.003465235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005842002038452457,"score_gpt":0.251187349223874,"score_spread":0.2453453471854215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}