{"id":"W2997876124","doi":"10.1186/s13008-019-0058-4","title":"The essentiality landscape of cell cycle related genes in human pluripotent and cancer cells","year":2019,"lang":"en","type":"article","venue":"Cell Division","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; United States-Israel Binational Science Foundation; Hebrew University of Jerusalem; Rosetrees Trust","keywords":"Biology; Cell cycle; Induced pluripotent stem cell; Carcinogenesis; Embryonic stem cell; Gene; Cell growth; Cell biology; Cancer cell; CRISPR; Cell cycle checkpoint; Genetics; Cell division; Cell; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003528132,0.000116653,0.0001391178,0.00004086542,0.00008219153,0.00002346711,0.0002160015,0.0001256247,0.00005528382],"category_scores_gemma":[0.000005244523,0.00008648789,0.00005693673,0.00009205615,0.00007124861,0.000004116293,0.0002856551,0.000111747,0.00001643889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001130427,"about_ca_system_score_gemma":0.00003471402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001398499,"about_ca_topic_score_gemma":0.00004114665,"domain_scores_codex":[0.9988638,0.0001119959,0.0002491912,0.0003263392,0.0001999457,0.0002487724],"domain_scores_gemma":[0.9993944,0.00002561934,0.00009770963,0.0003704634,0.00005357668,0.0000582898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002851701,0.00007349775,0.01554246,0.00008635908,0.000007750028,0.000001540682,0.00004064353,0.0004247956,0.9826409,0.00000475948,0.0002222845,0.0009265222],"study_design_scores_gemma":[0.000774849,0.0001076496,0.02181266,0.00002369116,0.000006125342,3.81563e-7,0.00006047731,0.0006441668,0.973159,0.00003883627,0.003259104,0.000113105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910343,0.005832983,0.00001198611,0.00004435136,0.0001413835,0.0002826686,0.00001047249,0.000004247529,0.002637659],"genre_scores_gemma":[0.9931006,0.003582904,0.00001686839,0.00001004584,0.0000198952,0.000008362191,0.00003116018,0.00001596973,0.003214181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009481924,"threshold_uncertainty_score":0.3526874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005842002038452457,"score_gpt":0.251187349223874,"score_spread":0.2453453471854215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}