{"id":"W2997894885","doi":"10.1016/j.nicl.2019.102156","title":"Body mass index is associated with smaller medial temporal lobe volume in those at risk for Alzheimer's disease","year":2019,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Genentech; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Alzheimer's Association; Fujirebio US; Pfizer; Biogen; BioClinica; National Institutes of Health; Johnson and Johnson Pharmaceutical Research and Development; Ohio State University; Janssen Alzheimer Immunotherapy Research And Development; AbbVie; Roche; University of Southern California; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Takeda Pharmaceuticals North America; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Drug Discovery Foundation; Merck; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative","keywords":"Body mass index; Temporal lobe; Brain size; Genetic predisposition; Cohort; Alzheimer's disease; Disease; Hazard ratio; Oncology; Medicine; Internal medicine; Psychology; Neuroscience; Confidence interval; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001383289,0.0002599981,0.0006006188,0.0001329499,0.00007458506,0.00004395442,0.0001959967,0.0001795511,0.001528878],"category_scores_gemma":[0.001878533,0.0002060806,0.0003021986,0.0002464562,0.0002524712,0.0001371246,0.0001619262,0.0007640456,0.0004090594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006143426,"about_ca_system_score_gemma":0.0003574034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000311331,"about_ca_topic_score_gemma":0.00005085672,"domain_scores_codex":[0.9967431,0.000432563,0.0006741812,0.0008338031,0.0006715918,0.0006446999],"domain_scores_gemma":[0.9975542,0.0008619169,0.0002198136,0.0004967699,0.0002703616,0.000596932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006908173,0.001126732,0.9823287,0.00002566929,0.0001939423,0.0005654655,0.00002549959,7.86334e-7,0.00009346406,0.000002277011,0.00712166,0.001607632],"study_design_scores_gemma":[0.0139762,0.002772037,0.9721133,0.0001007911,0.0004135768,0.000004064634,0.00002418534,0.00504141,0.00005436924,0.00007867144,0.005201495,0.0002199578],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939727,0.00008007104,0.00008845359,0.00194521,0.0003050755,0.002108934,0.0001576608,0.00006449469,0.001277354],"genre_scores_gemma":[0.991446,0.00007920081,0.0001183973,0.002090781,0.000253436,0.0001162755,0.000214752,0.00006546748,0.005615747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01021545,"threshold_uncertainty_score":0.9993839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05741802467390714,"score_gpt":0.3803684805554406,"score_spread":0.3229504558815334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}