{"id":"W2997894885","doi":"10.1016/j.nicl.2019.102156","title":"Body mass index is associated with smaller medial temporal lobe volume in those at risk for Alzheimer's disease","year":2019,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Genentech; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Alzheimer's Association; Fujirebio US; Pfizer; Biogen; BioClinica; National Institutes of Health; Johnson and Johnson Pharmaceutical Research and Development; Ohio State University; Janssen Alzheimer Immunotherapy Research And Development; AbbVie; Roche; University of Southern California; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Takeda Pharmaceuticals North America; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Drug Discovery Foundation; Merck; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative","keywords":"Body mass index; Temporal lobe; Brain size; Genetic predisposition; Cohort; Alzheimer's disease; Disease; Hazard ratio; Oncology; Medicine; Internal medicine; Psychology; Neuroscience; Confidence interval; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002345083,0.0002210489,0.0002231239,0.0005256119,0.000279129,0.0004336788,0.0001899087,0.0003770093,0.002065084],"category_scores_gemma":[0.001343737,0.0002016394,0.0003290344,0.0004645441,0.0001934438,0.0002149236,0.0002520363,0.0004648075,0.0002135957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001279827,"about_ca_system_score_gemma":0.0001310342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004194461,"about_ca_topic_score_gemma":0.006238713,"domain_scores_codex":[0.9999006,0.00002186401,0.00001142664,0.00003086845,0.00001838226,0.00001693015],"domain_scores_gemma":[0.9993443,0.00009323674,0.0003412902,0.00006113244,0.00004597195,0.0001140097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000293838,0.00002767977,0.995761,0.000008430558,0.00008136329,0.0001667442,0.00006839789,0.0000342266,0.001620643,0.00003427929,0.0001252588,0.001778227],"study_design_scores_gemma":[0.000002736236,0.00002157105,0.9996037,0.000001425912,0.00001530924,0.0001317945,0.00002036261,0.00007377871,0.0000339557,0.00003198894,0.00006226623,0.000001148425],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988392,0.0003035347,0.0001099956,0.00008165638,0.00001217832,0.000002938305,0.0001355942,0.000006178545,0.0005086933],"genre_scores_gemma":[0.9993652,0.00007960971,0.00008547794,0.0000322469,0.00001669957,0.000002876155,0.000108205,0.000003226017,0.0003065277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004194461,"threshold_uncertainty_score":0.00834012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05741802467390714,"score_gpt":0.3803684805554406,"score_spread":0.3229504558815334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}