{"id":"W2997921303","doi":"10.1159/000504341","title":"Neurodegenerative Patterns of Cognitive Clusters of Early-Onset Alzheimer’s Disease Subjects: Evidence for Disease Heterogeneity","year":2019,"lang":"en","type":"article","venue":"Dementia and Geriatric Cognitive Disorders","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Pfizer; Biogen; BioClinica; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Psychology; Statistical parametric mapping; Atrophy; Pittsburgh compound B; Posterior cingulate; Cognition; Alzheimer's disease; Neuroscience; Audiology; Internal medicine; Cognitive impairment; Magnetic resonance imaging; Disease; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001817004,0.0002526866,0.000465799,0.00181988,0.0004010138,0.0005694062,0.0004289856,0.0003026048,0.0008367259],"category_scores_gemma":[0.003253376,0.0001481786,0.00043115,0.0008683794,0.0005408007,0.0003078035,0.0006352627,0.0002107902,0.0001283976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002797852,"about_ca_system_score_gemma":0.0002360096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00267951,"about_ca_topic_score_gemma":0.002551134,"domain_scores_codex":[0.9990801,0.0002377371,0.0001407783,0.0002831364,0.000166368,0.00009189658],"domain_scores_gemma":[0.9976497,0.0008912053,0.0006760172,0.0003359623,0.0002638024,0.0001833639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005516848,0.00004087485,0.990968,0.00002833985,0.000271341,0.0001409686,0.0005491347,0.0001877641,0.003473925,0.00006493672,0.00008313545,0.003639816],"study_design_scores_gemma":[0.000007408599,0.00005658637,0.9987476,0.000003207781,0.00003306066,0.0002663867,0.000169894,0.0003386157,0.0002014199,0.0001182144,0.00005321306,0.000004389094],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993197,0.0001145365,0.0003120407,0.000008716614,0.000001650738,0.00001092816,0.0001160227,0.000005272453,0.0001111426],"genre_scores_gemma":[0.9996452,0.00001283006,0.0001515546,0.000003296,0.000001884995,0.000005320943,0.0001542671,0.000002522084,0.00002306569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00267951,"threshold_uncertainty_score":0.009609342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03074769873057251,"score_gpt":0.3323395660983849,"score_spread":0.3015918673678125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}