{"id":"W2997936339","doi":"10.1016/j.cgh.2019.12.019","title":"A User’s Guide to De-escalating Immunomodulator and Biologic Therapy in Inflammatory Bowel Disease","year":2019,"lang":"en","type":"review","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Janssen Pharmaceuticals; Janssen Biotech; Sandoz; Novartis; Ferring Pharmaceuticals; Crohn's and Colitis Foundation; Shire; Roche; Meso Scale Diagnostics; Merck; Prometheus; Takeda Pharmaceuticals U.S.A.; School of Public Health, University of California Berkeley; Pfizer; Tillotts Pharma; Boehringer Ingelheim","keywords":"Medicine; Inflammatory bowel disease; Disease; Intensive care medicine; Clinical trial; Risk stratification; De-escalation; Ulcerative colitis; Biologic Agents; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001655943,0.001625461,0.00310733,0.006178497,0.0003572049,0.002712254,0.002007369,0.002717743,0.08109828],"category_scores_gemma":[0.005897718,0.0006057768,0.001603279,0.003862745,0.0005271306,0.002192578,0.001808052,0.004036941,0.05996972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009356354,"about_ca_system_score_gemma":0.002304551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00172377,"about_ca_topic_score_gemma":0.006284917,"domain_scores_codex":[0.9988575,0.0002910417,0.0002090655,0.00008526537,0.0004701565,0.00008705851],"domain_scores_gemma":[0.996972,0.001403247,0.0003027145,0.0001040443,0.000883431,0.000334575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006237106,0.00004973408,0.00004411472,0.004515077,0.00003269688,0.00009630663,0.00002393444,0.0001209422,0.0004408863,0.00127767,0.5975409,0.3957954],"study_design_scores_gemma":[0.00005728806,0.00005021211,0.0002390506,0.003224646,0.0000313408,0.0003627506,0.00001197835,0.00009592563,0.00006933456,0.001353255,0.9944893,0.0000149552],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002418626,0.8842814,0.009031702,0.01691961,0.0166743,0.000609244,0.005421137,0.003237277,0.06358351],"genre_scores_gemma":[0.001451522,0.8207538,0.023275,0.02943303,0.0119665,0.001097346,0.006221428,0.0006372185,0.1051642],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.08109828,"threshold_uncertainty_score":0.2713008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03475145039854111,"score_gpt":0.3640704333205784,"score_spread":0.3293189829220373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}