{"id":"W2997947502","doi":"10.1016/j.jns.2019.10.260","title":"A safety, tolerability and biomarker update from an ongoing open-label extension study of RG6042 in adults with early manifest Huntington’s disease","year":2019,"lang":"en","type":"article","venue":"Journal of the Neurological Sciences","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council","keywords":"Tolerability; Huntington's disease; Medicine; Biomarker; Huntingtin; Oncology; Regimen; Internal medicine; Clinical endpoint; Huntingtin Protein; Adverse effect; Pharmacology; Disease; Clinical trial; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006528899,0.0006290418,0.002133186,0.0003485265,0.0004217663,0.001462186,0.000615811,0.001325958,0.002571344],"category_scores_gemma":[0.006691482,0.0002351096,0.001760696,0.000456679,0.0004669571,0.001246507,0.0003667664,0.00272456,0.0006702671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005569169,"about_ca_system_score_gemma":0.0008005846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005899829,"about_ca_topic_score_gemma":0.001938153,"domain_scores_codex":[0.998548,0.0005800019,0.0001956772,0.0001768833,0.0003935951,0.0001058033],"domain_scores_gemma":[0.9949508,0.002247165,0.0008771449,0.0004299383,0.001065749,0.0004292511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1375137,0.004074871,0.04632131,0.003068296,0.006334126,0.001707087,0.0007119376,0.001744514,0.05277451,0.0009376128,0.02423107,0.720581],"study_design_scores_gemma":[0.0823046,0.1950482,0.3915962,0.002234531,0.0210174,0.01057606,0.0008427866,0.005362102,0.0299488,0.004777683,0.2558564,0.0004352184],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8859691,0.0729676,0.007088938,0.009725354,0.001513989,0.001220914,0.006017887,0.0005507626,0.01494548],"genre_scores_gemma":[0.9609685,0.01485795,0.004178565,0.009019691,0.001228939,0.0005457012,0.006147754,0.0001085514,0.002944378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006528899,"threshold_uncertainty_score":0.03452855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04689619608237392,"score_gpt":0.304896655574816,"score_spread":0.258000459492442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}