{"id":"W2997965122","doi":"10.1126/sciimmunol.aaz8128","title":"A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade","year":2020,"lang":"en","type":"letter","venue":"Science Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Blockade; Immune checkpoint; Immunotherapy; Cancer immunotherapy; Myeloid cells; Stage (stratigraphy); Cancer research; Immune system; Perspective (graphical); PD-L1; Myeloid; Immunology; Biology; Medicine; Internal medicine; Computer science; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003691955,0.0009183174,0.001562065,0.000627869,0.001834718,0.002908858,0.001610469,0.02425527,0.004431821],"category_scores_gemma":[0.008006205,0.0004832655,0.001222679,0.0004119829,0.004461794,0.007795422,0.001462978,0.03642294,0.003688123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002790197,"about_ca_system_score_gemma":0.001942015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008277257,"about_ca_topic_score_gemma":0.001468405,"domain_scores_codex":[0.9977452,0.000775875,0.0002188448,0.0003271149,0.0006808389,0.0002520471],"domain_scores_gemma":[0.9953819,0.002704755,0.0001903881,0.0002339171,0.0007955088,0.0006934925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000294133,0.0001684288,0.0005290942,0.0002246494,0.00003459785,0.002935733,0.0001284258,0.0003022806,0.002215277,0.01533022,0.920172,0.05766518],"study_design_scores_gemma":[0.0003056694,0.0003680725,0.0005662272,0.0002672195,0.00003360814,0.003916552,0.0003088049,0.001014591,0.001197894,0.0464113,0.9455276,0.00008236976],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0004891172,0.01276928,0.0005325727,0.9574324,0.02718593,0.00001038834,0.00002543309,0.00005599008,0.001498886],"genre_scores_gemma":[0.007492282,0.01608351,0.001130587,0.8152673,0.1547639,0.00005330167,0.00003073253,0.00003058447,0.005147721],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02425527,"threshold_uncertainty_score":0.02024442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02718965976189477,"score_gpt":0.3083080192297383,"score_spread":0.2811183594678436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}