{"id":"W2998030065","doi":"10.1002/mus.26801","title":"Addressing heterogeneity in amyotrophic lateral sclerosis CLINICAL TRIALS","year":2020,"lang":"en","type":"review","venue":"Muscle & Nerve","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Amyotrophic lateral sclerosis; Clinical trial; Medicine; Disease; Biomarker; Precision medicine; Drug development; Personalized medicine; Bioinformatics; Internal medicine; Pathology; Drug; Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05527882,0.001313746,0.006182486,0.004094477,0.000448478,0.003988937,0.003050051,0.002850276,0.004761839],"category_scores_gemma":[0.1322,0.0007665721,0.004575113,0.004053175,0.001159218,0.002932192,0.002451278,0.002601882,0.0006019937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002825561,"about_ca_system_score_gemma":0.007882603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154062,"about_ca_topic_score_gemma":0.001855745,"domain_scores_codex":[0.9547353,0.02856977,0.008954817,0.001749192,0.005507732,0.0004830814],"domain_scores_gemma":[0.7868927,0.1957455,0.009980445,0.001941761,0.004789568,0.0006499874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005684964,0.00004012623,0.000497682,0.2631372,0.006671576,0.0001175106,0.0002181724,0.001065231,0.0002673806,0.006657355,0.00982434,0.7109349],"study_design_scores_gemma":[0.001807367,0.000843016,0.004258284,0.5507239,0.02862975,0.001110408,0.0004010249,0.001131096,0.0008074944,0.03016067,0.3799943,0.0001326529],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002167953,0.9961727,0.0009861855,0.001144276,0.0002849702,0.0002536161,0.00007385648,0.00001484425,0.0008526795],"genre_scores_gemma":[0.01019196,0.9825765,0.003102636,0.002165532,0.0005990685,0.0008986298,0.0001740327,0.00002038105,0.0002712657],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.05527882,"threshold_uncertainty_score":0.2923458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6936952136258205,"score_gpt":0.5474239739382132,"score_spread":0.1462712396876074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}