{"id":"W2998030867","doi":"10.1007/s00253-019-10217-2","title":"A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137","year":2020,"lang":"en","type":"article","venue":"Applied Microbiology and Biotechnology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Fundamental Research Funds for the Central Universities; Higher Education Discipline Innovation Project; State Key Laboratory of Bioreactor Engineering; National Natural Science Foundation of China","keywords":"Polyketide; Secondary metabolite; Metabolite; Chemistry; Virus; Stereochemistry; Strain (injury); Biological activity; Cytotoxicity; Active metabolite; Influenza A virus; Natural product; Mass spectrometry; Biology; Biochemistry; Biosynthesis; Gene; In vitro; Chromatography; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007276212,0.0004030341,0.0008341103,0.0001337865,0.000118219,0.00001636147,0.000214585,0.0009771186,0.0003114668],"category_scores_gemma":[0.00004721329,0.0002862557,0.00007263791,0.0003510187,0.0005006879,0.0000404059,0.0003262069,0.0007859269,0.0001091341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000349467,"about_ca_system_score_gemma":0.0001197256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007901804,"about_ca_topic_score_gemma":0.0001590285,"domain_scores_codex":[0.9981937,0.00003169324,0.0002808251,0.0009613628,0.00004366383,0.0004887306],"domain_scores_gemma":[0.9991469,0.00006348986,0.0001748168,0.000394616,0.00003171913,0.0001884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002874897,0.00007724405,0.001033949,0.0000343871,0.000269215,0.00006372795,0.00007843938,1.651563e-7,0.9684904,0.0002676457,0.001530347,0.02527954],"study_design_scores_gemma":[0.002585855,0.0005110749,0.005162825,0.00002950777,0.0002197732,0.000233301,0.00006248126,0.0000032979,0.963919,0.00008216947,0.02684248,0.0003481959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735099,0.000529845,0.0002300224,0.02450859,0.00005961887,0.0006106571,0.00009064516,0.0003273424,0.0001333797],"genre_scores_gemma":[0.9850312,0.0003483661,0.006287372,0.007993462,0.0001870238,0.000002802059,0.00007594094,0.00003576432,0.00003801988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02531213,"threshold_uncertainty_score":0.9999589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111646928444628,"score_gpt":0.2102250948853661,"score_spread":0.1991086256009198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}