{"id":"W2998030867","doi":"10.1007/s00253-019-10217-2","title":"A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137","year":2020,"lang":"en","type":"article","venue":"Applied Microbiology and Biotechnology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Fundamental Research Funds for the Central Universities; Higher Education Discipline Innovation Project; State Key Laboratory of Bioreactor Engineering; National Natural Science Foundation of China","keywords":"Polyketide; Secondary metabolite; Metabolite; Chemistry; Virus; Stereochemistry; Strain (injury); Biological activity; Cytotoxicity; Active metabolite; Influenza A virus; Natural product; Mass spectrometry; Biology; Biochemistry; Biosynthesis; Gene; In vitro; Chromatography; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008641085,0.0005573207,0.0003168798,0.0003514306,0.0001728263,0.0003647199,0.000206688,0.0003314612,0.0009900371],"category_scores_gemma":[0.00007513713,0.0001331305,0.0002725213,0.0003438544,0.0001677604,0.0003360222,0.0002640354,0.0004881083,0.00031643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001603503,"about_ca_system_score_gemma":0.0002654405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004192944,"about_ca_topic_score_gemma":0.000612081,"domain_scores_codex":[0.9999369,0.000008628675,0.000007010668,0.00001432039,0.00001644707,0.00001663945],"domain_scores_gemma":[0.999928,0.000006791472,0.0000096377,0.00000541701,0.000008983538,0.00004125131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002065604,0.00004199064,0.0001250523,0.00006830759,0.00001113184,0.000397885,0.00001730783,0.0002603102,0.9948237,0.0001055234,0.00005527688,0.003886899],"study_design_scores_gemma":[0.000106508,0.002179704,0.003119192,0.00002198598,0.00005981431,0.001012297,0.00006426594,0.001265913,0.9846359,0.0001977674,0.007305572,0.0000310758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871416,0.002137176,0.005648152,0.000145817,0.0001071965,0.00009678619,0.0008271156,0.0000983066,0.003797889],"genre_scores_gemma":[0.9904925,0.001116788,0.004262773,0.0000646212,0.00001850504,0.00002636052,0.001246482,0.00002323882,0.002748547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009900371,"threshold_uncertainty_score":0.003311992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111646928444628,"score_gpt":0.2102250948853661,"score_spread":0.1991086256009198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}