{"id":"W2998037364","doi":"10.3390/ijms21010329","title":"Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels","year":2020,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Birth, Development, and Health","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Fondation des Etoiles; Fonds de Recherche du Québec - Santé; Diabète Québec; American Diabetes Association","keywords":"Leptin; DNA methylation; Cord blood; Internal medicine; Endocrinology; Gene; Locus (genetics); Biology; Medicine; Genetics; Gene expression; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005838123,0.001204169,0.0008849642,0.0006660824,0.0006154646,0.0009940483,0.001507362,0.0007117378,0.01213566],"category_scores_gemma":[0.01602705,0.000458276,0.002390433,0.0008205824,0.0006502898,0.0007043684,0.001513642,0.001524158,0.0004921685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004231794,"about_ca_system_score_gemma":0.00179702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01287719,"about_ca_topic_score_gemma":0.007298918,"domain_scores_codex":[0.9945055,0.003188711,0.0001866722,0.001167579,0.0003756043,0.0005758937],"domain_scores_gemma":[0.990842,0.006541103,0.000847693,0.0008911871,0.0003963204,0.0004816502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004021434,0.0003944384,0.9354932,0.0005125402,0.01114614,0.002122591,0.001306686,0.0009791638,0.006218065,0.005103868,0.002456161,0.0302457],"study_design_scores_gemma":[0.000927923,0.002130143,0.93707,0.0003177297,0.01173661,0.002033473,0.002271218,0.01625215,0.003471695,0.01783589,0.005880464,0.00007273588],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503472,0.006231886,0.02302796,0.007085553,0.0005586307,0.000240143,0.004391962,0.0002977669,0.007818732],"genre_scores_gemma":[0.9941585,0.0006388359,0.002347415,0.0003869828,0.0001093439,0.0001429765,0.0005345529,0.00002474094,0.00165663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01287719,"threshold_uncertainty_score":0.0405978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04497282548874828,"score_gpt":0.3269902473586066,"score_spread":0.2820174218698583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}