{"id":"W2998071115","doi":"10.3390/microorganisms8010059","title":"Novel Sequence Feature of SecA Translocase Protein Unique to the Thermophilic Bacteria: Bioinformatics Analyses to Investigate Their Potential Roles","year":2019,"lang":"en","type":"article","venue":"Microorganisms","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Thermotoga maritima; Thermophile; Thermostability; Biology; Translocase; ATPase; Phylogenetic tree; Biochemistry; Bacteria; Gene; Conserved sequence; Multiple sequence alignment; Function (biology); Biophysics; Sequence alignment; Escherichia coli; Computational biology; Genetics; Peptide sequence; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508013,0.0002424454,0.0002380379,0.0000717417,0.00006311697,0.00004333678,0.000573216,0.0003324043,0.00003029162],"category_scores_gemma":[0.0000198442,0.0001614769,0.0000958881,0.0002586627,0.0001024682,0.000004620381,0.0002338624,0.0001430283,0.00003241163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001213076,"about_ca_system_score_gemma":0.0001096616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003135556,"about_ca_topic_score_gemma":0.00006512735,"domain_scores_codex":[0.9989958,0.00004255346,0.0002682626,0.0003088868,0.00009451415,0.0002899964],"domain_scores_gemma":[0.9990255,0.000003777344,0.0001071542,0.0006465621,0.0001126198,0.0001044257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000069965,0.00003230924,0.00001482128,0.00002737568,0.0000597127,0.00000100273,0.0002389056,0.00009085908,0.9979134,0.0000290211,0.0001342731,0.001388357],"study_design_scores_gemma":[0.0002638762,0.0005228019,0.0004097765,0.0000296065,0.0000203359,0.00004566037,0.0001683815,0.00003230321,0.9892614,0.00003170083,0.008994541,0.0002196261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920602,0.00009457664,0.003600649,0.002993648,0.0001233581,0.0007927298,0.0002815984,0.00001854419,0.0000347252],"genre_scores_gemma":[0.9865565,0.00002374131,0.01181421,0.001087661,0.00009773243,0.0000184396,0.00009734526,0.00003228956,0.0002720794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008860269,"threshold_uncertainty_score":0.6584839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01420199405376877,"score_gpt":0.2362337373929749,"score_spread":0.2220317433392061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}