{"id":"W2998071115","doi":"10.3390/microorganisms8010059","title":"Novel Sequence Feature of SecA Translocase Protein Unique to the Thermophilic Bacteria: Bioinformatics Analyses to Investigate Their Potential Roles","year":2019,"lang":"en","type":"article","venue":"Microorganisms","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Thermotoga maritima; Thermophile; Thermostability; Biology; Translocase; ATPase; Phylogenetic tree; Biochemistry; Bacteria; Gene; Conserved sequence; Multiple sequence alignment; Function (biology); Biophysics; Sequence alignment; Escherichia coli; Computational biology; Genetics; Peptide sequence; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002107918,0.0004025629,0.0005114312,0.001114447,0.0004444888,0.0005027194,0.0002646932,0.0003560705,0.002013999],"category_scores_gemma":[0.0005087109,0.0001210716,0.0007212122,0.001619157,0.0001614178,0.0003001186,0.0002816071,0.0003737,0.0008263423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196924,"about_ca_system_score_gemma":0.0005193207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001115381,"about_ca_topic_score_gemma":0.0020593,"domain_scores_codex":[0.9998367,0.00001785252,0.00001755684,0.00004946595,0.00005113215,0.00002732616],"domain_scores_gemma":[0.9997689,0.00004652283,0.00005996407,0.00001389177,0.00005781722,0.00005292421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002970814,0.0009398219,0.2042392,0.003748948,0.0006865164,0.007831617,0.0009993839,0.01843724,0.6287337,0.00281993,0.01334158,0.1152512],"study_design_scores_gemma":[0.0002351379,0.00117704,0.6219308,0.0003108565,0.001160474,0.009132392,0.001437667,0.2097711,0.09139578,0.003517773,0.05973384,0.000197143],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729153,0.00297576,0.008034595,0.0003129817,0.00005820722,0.0001244139,0.01203217,0.0006150256,0.002931509],"genre_scores_gemma":[0.9461938,0.001203921,0.02291931,0.0001421861,0.00003850296,0.0001388935,0.02799311,0.00009114097,0.001279252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002013999,"threshold_uncertainty_score":0.00673753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01420199405376877,"score_gpt":0.2362337373929749,"score_spread":0.2220317433392061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}