{"id":"W2998073984","doi":"10.1021/jacs.9b11761","title":"One-Pot Biocatalytic Transformation of Adipic Acid to 6-Aminocaproic Acid and 1,6-Hexamethylenediamine Using Carboxylic Acid Reductases and Transaminases","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Genome Canada","keywords":"Chemistry; Hexamethylenediamine; Adipic acid; Carboxylic acid; Aminocaproic acid; Organic chemistry; Biotransformation; Transformation (genetics); Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920949,0.0001283897,0.0003133604,0.00002785153,0.00003530201,0.00001432223,0.0001620174,0.00006449058,0.000003273534],"category_scores_gemma":[0.00007618687,0.00009797191,0.0002037566,0.0002359569,0.0002506132,0.00001910981,0.00004907106,0.0001092535,2.083688e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002994911,"about_ca_system_score_gemma":0.00005504761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001140231,"about_ca_topic_score_gemma":9.532557e-7,"domain_scores_codex":[0.9991146,0.00003826554,0.0003546582,0.0001691382,0.0001795661,0.0001437965],"domain_scores_gemma":[0.9992341,0.00001668643,0.0003529118,0.0001951405,0.0001137072,0.00008745898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000703919,0.00005005049,0.0005405204,0.00006641147,0.00009048744,7.115511e-8,0.0003889188,0.00002011444,0.9955629,0.000001370197,0.00004397635,0.003164759],"study_design_scores_gemma":[0.000400448,0.0003828042,0.001899985,0.00005016652,0.0001501956,0.00003500971,0.0006290206,0.0001167126,0.9960847,0.000007692727,0.0001266193,0.0001166237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970231,0.001648888,0.0008418484,0.0002755407,0.00004161154,0.000138589,0.00001927307,0.000001994541,0.000009156701],"genre_scores_gemma":[0.9972032,0.0004577468,0.001971535,0.0002381118,0.00008837513,0.000001779874,0.00001620483,0.00001355804,0.000009541865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003048136,"threshold_uncertainty_score":0.3995179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120384508713504,"score_gpt":0.2452052892983332,"score_spread":0.2340014442111982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}