{"id":"W2998134184","doi":"10.1093/ije/dyz242","title":"A Mendelian randomization analysis of circulating lipid traits and breast cancer risk","year":2019,"lang":"en","type":"article","venue":"International Journal of Epidemiology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Niilo Helanderin Säätiö; National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Cancer Council Victoria; Medical Research Council; National Institutes of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Fondazione Italiana per la Ricerca sul Cancro; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Norges Forskningsråd; Leids Universitair Medisch Centrum; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fonds Wetenschappelijk Onderzoek; Cancerfonden; Academy of Finland; National Breast Cancer Foundation; European Commission; KWF Kankerbestrijding; University of Southern California; Fondation du cancer du sein du Québec; Wellcome Trust; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; U.S. Department of Defense; Cancer Research UK; National Institute for Health and Care Research; European Social Fund; Agency for Science, Technology and Research; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Canadian Institutes of Health Research; General Secretariat for Research and Technology; McGill University Health Centre; Susan G. Komen; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Genome Canada; Deutsches Krebsforschungszentrum; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; University of Cambridge; Government of Canada; Helsingin ja Uudenmaan Sairaanhoitopiiri; University of California, Irvine; David F. and Margaret T. Grohne Family Foundation; Ministero dello Sviluppo Economico; VicHealth; Vanderbilt University; U.S. Department of Health and Human Services; Cancer Australia; Breast Cancer Research Foundation; McGill University","keywords":"Mendelian randomization; Breast cancer; Genome-wide association study; Odds ratio; Medicine; Oncology; Internal medicine; Confidence interval; Cancer; Genetic association; Genetics; Biology; Genotype; Single-nucleotide polymorphism; Genetic variants; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04218126,0.001467278,0.001596223,0.002307981,0.0006857138,0.001137757,0.001236036,0.001135108,0.004753517],"category_scores_gemma":[0.1085917,0.0004851376,0.003333895,0.001943543,0.001572512,0.001041337,0.0009745405,0.001048973,0.0004744141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009215487,"about_ca_system_score_gemma":0.001483294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002355722,"about_ca_topic_score_gemma":0.001190147,"domain_scores_codex":[0.9402722,0.04830992,0.001429892,0.005725698,0.003514198,0.0007480872],"domain_scores_gemma":[0.9240096,0.06123848,0.004989948,0.007686505,0.00167862,0.0003969726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01677189,0.0007032325,0.5063949,0.001281922,0.02848175,0.004695194,0.00128745,0.06497059,0.01750479,0.1041978,0.007133633,0.2465769],"study_design_scores_gemma":[0.004106395,0.007273204,0.2393673,0.0003702006,0.01212084,0.009242402,0.0002954428,0.5845467,0.007134337,0.1223297,0.0128591,0.0003543418],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3469243,0.001344593,0.6438167,0.0007711434,0.0002150782,0.001330041,0.001293315,0.001151226,0.003153529],"genre_scores_gemma":[0.8308029,0.0003760129,0.1653683,0.0002782078,0.00007935041,0.001307501,0.0007012276,0.0001258377,0.0009606763],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04218126,"threshold_uncertainty_score":0.2230784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01310163120567783,"score_gpt":0.3102625484942156,"score_spread":0.2971609172885378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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