{"id":"W2998134184","doi":"10.1093/ije/dyz242","title":"A Mendelian randomization analysis of circulating lipid traits and breast cancer risk","year":2019,"lang":"en","type":"article","venue":"International Journal of Epidemiology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Niilo Helanderin Säätiö; National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Cancer Council Victoria; Medical Research Council; National Institutes of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Fondazione Italiana per la Ricerca sul Cancro; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Norges Forskningsråd; Leids Universitair Medisch Centrum; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fonds Wetenschappelijk Onderzoek; Cancerfonden; Academy of Finland; National Breast Cancer Foundation; European Commission; KWF Kankerbestrijding; University of Southern California; Fondation du cancer du sein du Québec; Wellcome Trust; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; U.S. Department of Defense; Cancer Research UK; National Institute for Health and Care Research; European Social Fund; Agency for Science, Technology and Research; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Canadian Institutes of Health Research; General Secretariat for Research and Technology; McGill University Health Centre; Susan G. Komen; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Genome Canada; Deutsches Krebsforschungszentrum; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; University of Cambridge; Government of Canada; Helsingin ja Uudenmaan Sairaanhoitopiiri; University of California, Irvine; David F. and Margaret T. Grohne Family Foundation; Ministero dello Sviluppo Economico; VicHealth; Vanderbilt University; U.S. Department of Health and Human Services; Cancer Australia; Breast Cancer Research Foundation; McGill University","keywords":"Mendelian randomization; Breast cancer; Genome-wide association study; Odds ratio; Medicine; Oncology; Internal medicine; Confidence interval; Cancer; Genetic association; Genetics; Biology; Genotype; Single-nucleotide polymorphism; Genetic variants; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001185499,0.00009375715,0.0004902401,0.0002504582,0.00001584013,0.000004864789,0.0001720773,0.0001192589,0.0001112259],"category_scores_gemma":[0.0007170637,0.00007772238,0.0002594625,0.000110615,0.00006141693,0.00001018736,0.00003907158,0.0001257832,5.599907e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002032572,"about_ca_system_score_gemma":0.00007533351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001640779,"about_ca_topic_score_gemma":0.00007031613,"domain_scores_codex":[0.9986119,0.0002978255,0.000672394,0.0001686397,0.000122258,0.0001270104],"domain_scores_gemma":[0.9982455,0.0002106639,0.0009504884,0.0000752757,0.0004621383,0.00005593029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001800686,0.0000646445,0.6798167,0.00001729969,0.007382878,5.852011e-7,0.0002086831,0.03498942,0.2192172,0.0005725485,0.006956894,0.04897246],"study_design_scores_gemma":[0.006160502,0.0001723575,0.9073221,0.00005800305,0.00125677,0.0002619749,0.0001043949,0.006207231,0.0009264816,0.0004930083,0.07680953,0.0002276285],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850999,0.001968738,0.006833077,0.002815374,0.002979024,0.00007137397,0.0001303869,0.000001827185,0.0001003536],"genre_scores_gemma":[0.9884102,0.003306109,0.0007951612,0.001856219,0.00554468,0.000002598809,0.00002955264,0.000008357083,0.00004714185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2275054,"threshold_uncertainty_score":0.3169427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01310163120567783,"score_gpt":0.3102625484942156,"score_spread":0.2971609172885378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}