{"id":"W2998213518","doi":"10.1016/j.trecan.2019.11.005","title":"Targeting NAD+ Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma","year":2019,"lang":"en","type":"article","venue":"Trends in cancer","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Beatrice Hunter Cancer Research Institute; University of New Brunswick; Saint John Regional Hospital; Nova Scotia Health Authority; Dalhousie University","funders":"Terry Fox Research Institute; Canadian Cancer Society; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society; Dalhousie Medical Research Foundation; Beatrice Hunter Cancer Research Institute","keywords":"CD38; NAD+ kinase; Immunotherapy; Multiple myeloma; Antibody; Medicine; Cancer research; Enzyme; Chemistry; Immunology; Biology; Biochemistry; Immune system; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001744896,0.0001238409,0.0002024294,0.0000941479,0.00001979151,0.000007613589,0.0001574953,0.00008231644,0.0005088768],"category_scores_gemma":[0.00004413989,0.0001184912,0.0001036427,0.0001966795,0.00002270041,0.000002112721,0.00003272968,0.00005942326,0.00001159797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000178113,"about_ca_system_score_gemma":0.00002978942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005518884,"about_ca_topic_score_gemma":0.0001034918,"domain_scores_codex":[0.999143,0.00004637038,0.0002162899,0.0002695525,0.0001112464,0.0002135405],"domain_scores_gemma":[0.9995485,0.00002818789,0.00007488289,0.0002659236,0.00004212631,0.00004036545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002505805,0.00004555398,0.01166485,0.00001420778,0.00003752714,7.605261e-7,0.00004667129,0.009726033,0.9238058,0.000002775775,0.0005928839,0.05381231],"study_design_scores_gemma":[0.0008168247,0.00009400614,0.02344504,0.00006828086,0.00001450386,3.778566e-7,0.00002684496,0.001032725,0.9385194,0.000003136025,0.03575396,0.0002248705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965596,0.002296298,0.0002573932,0.0001668028,0.0002875655,0.00007304209,0.00005043585,0.000009494724,0.0002994034],"genre_scores_gemma":[0.9980416,0.0001172052,0.0008585822,0.0002507643,0.0001034042,0.0000386229,0.00001919345,0.00002853238,0.0005420776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05358744,"threshold_uncertainty_score":0.5571844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01268873108035984,"score_gpt":0.2810271772785103,"score_spread":0.2683384461981504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}