{"id":"W2998245121","doi":"10.1016/j.theriogenology.2019.12.020","title":"The age of the bull influences the transcriptome and epigenome of blastocysts produced by IVF","year":2019,"lang":"en","type":"article","venue":"Theriogenology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"L'Alliance Boviteq; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Transcriptome; Epigenome; Biology; Andrology; Embryo; Offspring; Reproductive technology; Sperm; Blastocyst; Embryo quality; Genetics; In vitro fertilisation; Embryogenesis; Gene; DNA methylation; Pregnancy; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004177769,0.0001442053,0.0004174724,0.0003663097,0.0002358051,0.0008721565,0.0001841277,0.0002995692,0.003407587],"category_scores_gemma":[0.0007375024,0.0002651936,0.0002023109,0.0002662298,0.0002733553,0.0004782451,0.0003368179,0.0004985544,0.0003954802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002949566,"about_ca_system_score_gemma":0.0002222423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003427838,"about_ca_topic_score_gemma":0.004384411,"domain_scores_codex":[0.9997473,0.00005991756,0.00001378262,0.00007019196,0.00004822452,0.00006045595],"domain_scores_gemma":[0.9995677,0.0001614429,0.00009347217,0.00003170703,0.00005534368,0.00009042629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002756947,0.00009730985,0.08679279,0.00009407501,0.0001631362,0.0003830338,0.0006902447,0.0001710491,0.898681,0.0003458182,0.0003054319,0.00951923],"study_design_scores_gemma":[0.00002634813,0.0006120632,0.938301,0.00003186546,0.0002465588,0.0002918841,0.001032351,0.0005345352,0.056237,0.0001670786,0.002491418,0.00002793159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958567,0.001610824,0.0007257316,0.00008622637,0.00003881489,0.000010004,0.0003747266,0.0000122283,0.001284691],"genre_scores_gemma":[0.9950154,0.0008081055,0.0003614778,0.0001482611,0.00002186899,0.00001140739,0.0003597596,0.00002631082,0.003247455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003427838,"threshold_uncertainty_score":0.01139957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006661645303305166,"score_gpt":0.221384913185648,"score_spread":0.2147232678823429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}