{"id":"W2998325113","doi":"10.1093/neuonc/noz175.032","title":"ATIM-33. INTERIM RESULTS OF A PHASE II MULTI-CENTER STUDY OF ONCOLYTIC ADENOVIRUS DNX-2401 WITH PEMBROLIZUMAB FOR RECURRENT GLIOBLASTOMA; CAPTIVE STUDY (KEYNOTE-192)","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Pembrolizumab; Medicine; Adverse effect; Oncology; Internal medicine; Oncolytic adenovirus; Oncolytic virus; Phases of clinical research; Cohort; Toxicity; Surgery; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003883722,0.001618084,0.001123416,0.0004039272,0.0006187907,0.001172844,0.0012263,0.001425807,0.005269438],"category_scores_gemma":[0.001011025,0.0006273916,0.0008677404,0.0003379269,0.0005689478,0.0006822951,0.0003575026,0.002733643,0.001675486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001082483,"about_ca_system_score_gemma":0.001858126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001390864,"about_ca_topic_score_gemma":0.00296182,"domain_scores_codex":[0.9992982,0.0003551909,0.00002722368,0.00009385459,0.00007375181,0.0001516832],"domain_scores_gemma":[0.9992404,0.00009102073,0.0001287039,0.00007638488,0.00005553892,0.000408071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4922304,0.05629941,0.0225161,0.001194505,0.002288265,0.001237731,0.0004444168,0.003282196,0.1330978,0.001126998,0.04243268,0.2438495],"study_design_scores_gemma":[0.4276758,0.4699472,0.04968983,0.00008813668,0.001120087,0.001127738,0.00007316152,0.002204224,0.01579921,0.0006062165,0.03160789,0.00006048309],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9472861,0.005776295,0.003754803,0.001918411,0.0004237286,0.01164697,0.01256557,0.0006811411,0.01594693],"genre_scores_gemma":[0.9466427,0.002387834,0.007465214,0.002598962,0.0003894348,0.01157186,0.01851809,0.0001242778,0.01030162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005269438,"threshold_uncertainty_score":0.02053934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04000655458309873,"score_gpt":0.375543500457988,"score_spread":0.3355369458748892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}