{"id":"W2998325113","doi":"10.1093/neuonc/noz175.032","title":"ATIM-33. INTERIM RESULTS OF A PHASE II MULTI-CENTER STUDY OF ONCOLYTIC ADENOVIRUS DNX-2401 WITH PEMBROLIZUMAB FOR RECURRENT GLIOBLASTOMA; CAPTIVE STUDY (KEYNOTE-192)","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Pembrolizumab; Medicine; Adverse effect; Oncology; Internal medicine; Oncolytic adenovirus; Oncolytic virus; Phases of clinical research; Cohort; Toxicity; Surgery; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006513337,0.0004073547,0.0008509213,0.0002568081,0.0000978858,0.00001183306,0.000646133,0.0002281128,0.0000321742],"category_scores_gemma":[0.0003694335,0.0003271275,0.0001674066,0.0002887156,0.0002125708,0.00001168552,0.0004793627,0.0003539238,0.00001240155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001668026,"about_ca_system_score_gemma":0.0007483579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007927819,"about_ca_topic_score_gemma":0.003164867,"domain_scores_codex":[0.9962938,0.0007388097,0.0008795279,0.001025574,0.0004372877,0.0006249317],"domain_scores_gemma":[0.9973928,0.0002132457,0.0005938686,0.001020677,0.0005628585,0.0002165382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2464512,0.03372498,0.0007957366,0.00005986176,0.0004666857,0.00003983241,0.003929823,0.0001519957,0.7025655,8.070293e-7,0.000553618,0.01125993],"study_design_scores_gemma":[0.09492349,0.6357169,0.000215374,0.00003143702,0.0001171503,0.0000296894,0.003147412,0.0004698897,0.258932,0.000001638807,0.00611684,0.0002982801],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936802,0.00008119109,0.00008767413,0.0001051928,0.0003350824,0.005160156,0.0003655238,0.00001931105,0.0001656923],"genre_scores_gemma":[0.9988201,0.00003249596,0.0001688507,0.0001464632,0.0001144247,0.0004065845,0.00005883453,0.00008365407,0.0001686402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6019918,"threshold_uncertainty_score":0.9999181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04000655458309873,"score_gpt":0.375543500457988,"score_spread":0.3355369458748892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}