{"id":"W2998351940","doi":"10.3390/cells9010120","title":"GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"National Institute of General Medical Sciences; National Institutes of Health; American Heart Association","keywords":"Sepsis; Macrophage polarization; Inflammation; Immunology; Macrophage; Septic shock; Medicine; Blockade; Macrophage migration inhibitory factor; Proinflammatory cytokine; Cytokine; Phenotype; Receptor; Biology; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002518542,0.0007348813,0.0005307556,0.0007734571,0.0002447237,0.000267811,0.00043057,0.0008983338,0.0018874],"category_scores_gemma":[0.0001322382,0.0003170493,0.0005722067,0.0002551117,0.0005466106,0.0003232716,0.0002602529,0.001677151,0.0005171719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003717932,"about_ca_system_score_gemma":0.000588849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009797497,"about_ca_topic_score_gemma":0.001278872,"domain_scores_codex":[0.9997697,0.00002996227,0.00002876603,0.0000454858,0.00003918321,0.00008682902],"domain_scores_gemma":[0.9997421,0.00001226641,0.00007815965,0.00002243381,0.00001934553,0.0001256554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002188561,0.0003825859,0.0002415871,0.00008842296,0.00001639781,0.00009542648,0.00003137982,0.0001042165,0.9939597,0.0001948451,0.0001695085,0.002527499],"study_design_scores_gemma":[0.0009409585,0.00590788,0.01038061,0.000069711,0.00009575358,0.0008217367,0.0001485335,0.001927385,0.9723359,0.0004576278,0.006876621,0.00003730055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897999,0.002248449,0.003311731,0.0007414597,0.0001689572,0.0000965498,0.001749919,0.0004697403,0.001413297],"genre_scores_gemma":[0.9823156,0.002008536,0.005132569,0.0004406389,0.0000607901,0.0003212458,0.002213848,0.0001395569,0.007367169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0018874,"threshold_uncertainty_score":0.006314039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04535107785461185,"score_gpt":0.2863007256312886,"score_spread":0.2409496477766767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}