{"id":"W2998365747","doi":"10.1101/mcs.a004713","title":"Fluorouracil sensitivity in a head and neck squamous cell carcinoma with a somatic <i>DPYD</i> structural variant","year":2019,"lang":"en","type":"article","venue":"Molecular Case Studies","topic":"Cancer Diagnosis and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; Pancreas Centre (Canada); BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre","funders":"Common Fund; NIH Office of the Director; National Human Genome Research Institute; National Cancer Institute; BC Cancer Foundation; National Institutes of Health; Genome British Columbia; Genome Canada","keywords":"DPYD; Fluorouracil; Somatic cell; Head and neck; Medicine; Head and neck squamous-cell carcinoma; Basal cell; Oncology; Internal medicine; Cancer research; Head and neck cancer; Genetics; Biology; Cancer; Pharmacogenetics; Surgery; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001296563,0.0003176844,0.0003719378,0.0004351051,0.000642937,0.0003833497,0.0002980318,0.001130156,0.0008147656],"category_scores_gemma":[0.0005773159,0.0001977159,0.0005325198,0.0003526421,0.0004456783,0.0001705484,0.0002556284,0.0006028021,0.0002556632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001045456,"about_ca_system_score_gemma":0.0003704392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01164225,"about_ca_topic_score_gemma":0.01693509,"domain_scores_codex":[0.9998094,0.0000133159,0.00001894656,0.00006237718,0.00004278426,0.00005310554],"domain_scores_gemma":[0.9997728,0.0000552465,0.00004379337,0.00001430858,0.00003526014,0.00007862857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0008885605,0.000158139,0.06786761,0.000102212,0.00006767659,0.8142596,0.0005272817,0.000585287,0.1040342,0.0003200344,0.0008492461,0.01034014],"study_design_scores_gemma":[0.00008506377,0.00162061,0.2821496,0.0000461543,0.000188096,0.6844362,0.0004325711,0.003145937,0.02370382,0.0003563704,0.003773989,0.00006169622],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996979,0.000579227,0.00034634,0.0003772547,0.00004183648,0.00003808346,0.0002086683,0.00002404241,0.001405507],"genre_scores_gemma":[0.9990121,0.0001292374,0.0002511391,0.000173732,0.0000143043,0.000003914282,0.00009138197,0.000005555957,0.0003185702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01164225,"threshold_uncertainty_score":0.02314895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092581536366155,"score_gpt":0.2549111362161506,"score_spread":0.2439853208524891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}