{"id":"W2998402381","doi":"10.1016/j.nucmedbio.2019.12.009","title":"A comparison of DFO and DFO* conjugated to trastuzumab-DM1 for complexing 89Zr – In vitro stability and in vivo microPET/CT imaging studies in NOD/SCID mice with HER2-positive SK-OV-3 human ovarian cancer xenografts","year":2019,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"Terry Fox Foundation; University of Toronto; Ontario Institute for Cancer Research","keywords":"In vivo; Nod; In vitro; Conjugated system; Trastuzumab; Chemistry; Chelation; Cancer research; Pharmacology; Medicine; Cancer; Biochemistry; Internal medicine; Biology; Organic chemistry; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002603724,0.0001415066,0.0006414425,0.00009650838,0.00004309051,0.00000341761,0.00004318063,0.0000350838,0.00003732497],"category_scores_gemma":[0.00004394643,0.0001034442,0.00001232035,0.0001855682,0.0005554006,0.00002513512,0.00003986444,0.0001942773,2.884783e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005876497,"about_ca_system_score_gemma":0.00001975034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009795717,"about_ca_topic_score_gemma":0.0004377185,"domain_scores_codex":[0.9990098,0.00005225642,0.0003339132,0.0003430014,0.00004550433,0.0002155013],"domain_scores_gemma":[0.9994777,0.000206848,0.00007035155,0.00009280717,0.00006193866,0.00009033769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001060424,0.0001156808,0.1664373,0.000313591,0.00003387652,0.000006483963,0.003037577,7.237721e-7,0.8284033,0.00004852514,0.00005294946,0.0004896071],"study_design_scores_gemma":[0.03591635,0.004602458,0.3677871,0.003809874,0.0004111035,0.0002817087,0.04896113,0.004419233,0.5240337,0.0003010959,0.008630061,0.0008462027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935946,0.001342382,0.000006185901,0.004063883,0.00001784915,0.0007467219,0.00003815569,0.000009032185,0.0001811709],"genre_scores_gemma":[0.9986976,0.00009438453,0.0003450803,0.0007550991,0.00003907048,0.00003009759,0.00002065672,0.00001106067,0.00000692379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3043696,"threshold_uncertainty_score":0.4218332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1063878528001507,"score_gpt":0.4315869890611297,"score_spread":0.325199136260979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}