{"id":"W2998402381","doi":"10.1016/j.nucmedbio.2019.12.009","title":"A comparison of DFO and DFO* conjugated to trastuzumab-DM1 for complexing 89Zr – In vitro stability and in vivo microPET/CT imaging studies in NOD/SCID mice with HER2-positive SK-OV-3 human ovarian cancer xenografts","year":2019,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"Terry Fox Foundation; University of Toronto; Ontario Institute for Cancer Research","keywords":"In vivo; Nod; In vitro; Conjugated system; Trastuzumab; Chemistry; Chelation; Cancer research; Pharmacology; Medicine; Cancer; Biochemistry; Internal medicine; Biology; Organic chemistry; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002189835,0.0002430289,0.0001935268,0.0001560558,0.0001087208,0.0001941211,0.0001929624,0.0002755451,0.0005798772],"category_scores_gemma":[0.0003575527,0.0001388927,0.0001407418,0.0001413998,0.000131936,0.0002131546,0.00009008191,0.000171444,0.0001191658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002804475,"about_ca_system_score_gemma":0.0001541455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002509517,"about_ca_topic_score_gemma":0.002460736,"domain_scores_codex":[0.9998883,0.00001705046,0.000008027521,0.00002954688,0.00002065914,0.00003652996],"domain_scores_gemma":[0.9998842,0.00003503114,0.00003089083,0.000007454117,0.0000220715,0.00002030679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003143065,0.00001627362,0.0001289191,0.00003545714,0.000005714982,0.00001368919,0.0000128506,0.000132501,0.9978622,0.00004785525,0.00002585744,0.001404479],"study_design_scores_gemma":[0.00001020589,0.0002570612,0.001413651,0.000002671801,0.00001689975,0.00004969198,0.000007071108,0.0009537662,0.9964036,0.000007245377,0.0008729639,0.000005320192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962179,0.000980489,0.001893532,0.00003485719,0.00001705806,0.00001391509,0.0001074103,0.00001987266,0.0007149394],"genre_scores_gemma":[0.9957039,0.0006576559,0.00215232,0.00002382453,0.00000695857,0.00001465537,0.000183604,0.000015385,0.00124174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002509517,"threshold_uncertainty_score":0.004989862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1063878528001507,"score_gpt":0.4315869890611297,"score_spread":0.325199136260979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}