{"id":"W2998468579","doi":"10.3390/pharmaceutics12010030","title":"Engineered Nanodelivery Systems to Improve DNA Vaccine Technologies","year":2020,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"DNA vaccination; Immune system; Computational biology; Biology; Immunology; Virology; Medicine; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004763762,0.0007751775,0.0006989657,0.001468577,0.0001927258,0.0007191998,0.0006622038,0.001023467,0.002788019],"category_scores_gemma":[0.0004455645,0.0003170626,0.0004635177,0.0009691876,0.0003317379,0.001141533,0.0005701546,0.001666655,0.00142514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005860841,"about_ca_system_score_gemma":0.0005295822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005156433,"about_ca_topic_score_gemma":0.0007362099,"domain_scores_codex":[0.9998152,0.00002920375,0.00001620502,0.00003291184,0.00008154511,0.00002503065],"domain_scores_gemma":[0.999874,0.00006102385,0.0000195244,0.000004466604,0.00003165519,0.000009208207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007046833,0.0001512896,0.0001474772,0.0220971,0.0000962604,0.0003503202,0.000105617,0.00121775,0.02981838,0.02124458,0.02879573,0.895905],"study_design_scores_gemma":[0.00001168015,0.0001015686,0.0002042823,0.001223472,0.00005056385,0.0004999082,0.00002366494,0.0002179781,0.006610092,0.001988634,0.9890514,0.00001669234],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006908496,0.9937715,0.001242536,0.0003636592,0.0004756753,0.00002063763,0.00003352995,0.00002962746,0.003372024],"genre_scores_gemma":[0.003256384,0.992425,0.001297402,0.0003615028,0.0001543477,0.00003259995,0.00006437441,0.00000722972,0.002401059],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002788019,"threshold_uncertainty_score":0.009326816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04672788407179804,"score_gpt":0.3435271141115817,"score_spread":0.2967992300397836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}