{"id":"W2998514809","doi":"10.1016/j.celrep.2019.11.090","title":"Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; McGill University","funders":"National Center for Research Resources; Canadian Institutes of Health Research; National Institutes of Health; Deutsche Forschungsgemeinschaft; University of Minnesota","keywords":"Adipose triglyceride lipase; Lipidome; AMPK; Lipid metabolism; Cell biology; Biology; Adipose tissue; Lipid droplet; Lipid oxidation; Phospholipase A2; Phospholipase; Protein kinase A; Biochemistry; Kinase; Enzyme; Lipolysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003244738,0.0003332239,0.0003364796,0.00003039034,0.0001143343,0.00007444752,0.0002690341,0.0003268041,0.000117567],"category_scores_gemma":[0.00003574075,0.0003427255,0.0002473991,0.0001300902,0.0000757121,0.00001120854,0.0002284879,0.0001660159,0.0001464064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005187927,"about_ca_system_score_gemma":0.0001311875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005666139,"about_ca_topic_score_gemma":0.00001758312,"domain_scores_codex":[0.9975324,0.00005998762,0.0005724468,0.0009979913,0.000311555,0.0005255989],"domain_scores_gemma":[0.9980685,0.000007680056,0.0003244095,0.001320344,0.000129272,0.0001497752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006517212,0.0001947299,0.01859749,0.00008174204,0.00006531282,0.00006933454,0.0005121272,0.00630177,0.9653349,0.00002016992,0.006335251,0.002421999],"study_design_scores_gemma":[0.00120026,0.0004950357,0.00531752,0.00004705965,0.0001348305,0.000501873,0.0002420611,0.001526255,0.4160093,0.001010836,0.5721751,0.001339876],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826636,0.001833601,0.00443822,0.0001264398,0.001551764,0.0004402644,0.000006336081,0.00005887447,0.008880912],"genre_scores_gemma":[0.9925249,0.0006027165,0.003037793,0.0004376238,0.0009635743,0.00001541798,0.0001260152,0.00005984217,0.002232122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5658398,"threshold_uncertainty_score":0.9999025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009030067988699637,"score_gpt":0.2172714967194742,"score_spread":0.2082414287307746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}