{"id":"W2998564252","doi":"10.1371/journal.pone.0226856","title":"Hipk is required for JAK/STAT activity during development and tumorigenesis","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"stat; JAK-STAT signaling pathway; Janus kinase; STAT4; Phenocopy; Biology; Cell biology; Signal transduction; SOCS3; Cancer research; Effector; Carcinogenesis; STAT3; Genetics; Phenotype; Gene; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008978973,0.0002808743,0.0001701809,0.0003093247,0.0002719829,0.000375635,0.0002069925,0.0001960403,0.001165811],"category_scores_gemma":[0.0001588215,0.0001804356,0.0001813766,0.0001484237,0.0003221084,0.0001857156,0.0004036306,0.0004058913,0.0005509578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004269701,"about_ca_system_score_gemma":0.0003892402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006314263,"about_ca_topic_score_gemma":0.001047881,"domain_scores_codex":[0.9998794,0.00001103015,0.00001718843,0.00002543493,0.00004073263,0.0000262506],"domain_scores_gemma":[0.9997979,0.00001740821,0.00008526331,0.00001792955,0.00001146805,0.00007014873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009039079,0.0000060647,0.0005989639,0.00002832894,0.000004975592,0.000188019,0.000007871084,0.00006785011,0.9977137,0.0001968201,0.00004116495,0.001055931],"study_design_scores_gemma":[0.00002533787,0.0000629909,0.03761077,0.000009465578,0.00002195373,0.001425371,0.00004324964,0.001743829,0.955687,0.0002357124,0.003121881,0.00001241296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912586,0.001282449,0.004592706,0.0001344344,0.00002562396,0.00001740123,0.0009564784,0.0002161856,0.001516208],"genre_scores_gemma":[0.9964268,0.0002319219,0.001351919,0.00003300656,0.000005239581,0.00001146348,0.0006172965,0.00002877214,0.001293614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165811,"threshold_uncertainty_score":0.003899992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03474506936361843,"score_gpt":0.2257109367594199,"score_spread":0.1909658673958015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}