{"id":"W2998593800","doi":"10.3324/haematol.2019.235291","title":"The long non-coding RNA <i>Cancer Susceptibility 15</i> (<i>CASC15</i>) is induced by isocitrate dehydrogenase (IDH) mutations and maintains an immature phenotype in adult acute myeloid leukemia","year":2020,"lang":"en","type":"letter","venue":"Haematologica","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"BC Cancer Agency; Universität Ulm; Helmholtz Zentrum München; School of Medicine, Stanford University; Ludwig-Maximilians-Universität München","keywords":"Isocitrate dehydrogenase; IDH1; Molecular biology; Long non-coding RNA; RNA; Cancer research; Chemistry; Biology; Gene; Mutation; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.0007302768,0.00148036,0.001511327,0.0002900574,0.001081165,0.0004703326,0.001772696,0.003524744,0.0002317332],"category_scores_gemma":[0.000497379,0.001279764,0.0006408947,0.0009569242,0.0008756648,0.00005757905,0.0009848588,0.003368341,0.00007654292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007161897,"about_ca_system_score_gemma":0.001358295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000837153,"about_ca_topic_score_gemma":0.002272757,"domain_scores_codex":[0.9914654,0.0009999747,0.001364306,0.002914424,0.001134686,0.002121176],"domain_scores_gemma":[0.9957195,0.0002140634,0.0007851518,0.002018488,0.0006847296,0.000578062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004536896,0.00009069162,0.000007938932,0.0002908523,0.0007228211,0.001268375,0.00043745,0.00004544895,0.8497019,0.000259652,0.1457151,0.001006094],"study_design_scores_gemma":[0.004460329,0.001511763,0.0002718205,0.000572466,0.000906613,0.0005958714,0.0002185447,0.002998438,0.772635,0.001685351,0.2104842,0.00365957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8593558,0.01507728,0.005822426,0.1075477,0.001114047,0.005710911,0.002963663,0.0003451077,0.002063062],"genre_scores_gemma":[0.9115128,0.01131542,0.0007216476,0.0675967,0.001148655,0.001222332,0.004620546,0.0004185084,0.001443408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07706691,"threshold_uncertainty_score":0.9997945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262041539646823,"score_gpt":0.2663825028896349,"score_spread":0.2537620874931666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}