{"id":"W2998644011","doi":"10.1136/annrheumdis-2019-216487","title":"Efficacy and safety of NI-0101, an anti-toll-like receptor 4 monoclonal antibody, in patients with rheumatoid arthritis after inadequate response to methotrexate: a phase II study","year":2019,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Medicine; Rheumatoid arthritis; Tolerability; Internal medicine; Placebo; Adverse effect; Immunology; Population; Methotrexate; Rheumatism; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001604816,0.001157184,0.00229678,0.00042881,0.0004488747,0.0007951209,0.0007702755,0.001365092,0.001849329],"category_scores_gemma":[0.00121448,0.000567713,0.001497324,0.0003562631,0.001072607,0.0008899561,0.0002327703,0.002923629,0.0007011747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005393904,"about_ca_system_score_gemma":0.000869225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005973208,"about_ca_topic_score_gemma":0.001003625,"domain_scores_codex":[0.9994498,0.0002964948,0.00004254715,0.00006724599,0.00005344742,0.00009043356],"domain_scores_gemma":[0.9989524,0.0003163707,0.0001999075,0.00008814629,0.00006286346,0.0003802921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7974551,0.04697531,0.01027891,0.0007989587,0.001828133,0.0003527296,0.0002802018,0.001630261,0.03730255,0.0001895639,0.001399815,0.1015083],"study_design_scores_gemma":[0.422112,0.5514876,0.01986271,0.00003822491,0.0008605352,0.0003614606,0.000072072,0.001162776,0.00261258,0.0001066015,0.001276686,0.00004670881],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953531,0.002668257,0.0002714173,0.0001984698,0.00007107425,0.0003340665,0.0002259504,0.00003699872,0.0008407246],"genre_scores_gemma":[0.9948671,0.001551064,0.0005520338,0.0004726199,0.0001857088,0.0004431957,0.0007022955,0.00001326773,0.00121275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00229678,"threshold_uncertainty_score":0.008487165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01592410041404283,"score_gpt":0.3193986161312354,"score_spread":0.3034745157171926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}