{"id":"W2998707963","doi":"10.1016/j.bbi.2019.12.014","title":"A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE","year":2019,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University; NOSM University; Université de Moncton","funders":"National Institutes of Health; National Institute of General Medical Sciences; Multiple Sclerosis Society of Canada","keywords":"Agonist; Nicotinic agonist; Methyllycaconitine; Inflammation; Pharmacology; Experimental autoimmune encephalomyelitis; Acetylcholine receptor; Chemistry; Cytokine; Receptor; Nicotinic acetylcholine receptor; Immunology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004276418,0.0002327789,0.0003022783,0.00005809417,0.000103336,0.00002976341,0.0001805203,0.0001985461,0.0001032634],"category_scores_gemma":[0.0001609565,0.0002211078,0.00008512977,0.00009937202,0.0001747818,0.0000159732,0.000336804,0.000197882,0.000009988355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001393732,"about_ca_system_score_gemma":0.00004160884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001482076,"about_ca_topic_score_gemma":0.00004567665,"domain_scores_codex":[0.9987145,0.000165219,0.000399984,0.000343556,0.0001369492,0.0002397783],"domain_scores_gemma":[0.9990574,0.00005781596,0.0002034339,0.0004809984,0.0001126746,0.00008771276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000629456,0.0001409004,0.1342345,0.00003986115,0.00003236789,7.165765e-8,0.0002526373,0.000002969027,0.8595711,0.0000119412,0.000459658,0.005191019],"study_design_scores_gemma":[0.001904778,0.0006588374,0.1159991,0.00005110669,0.00007965595,0.00002021931,0.0008044697,0.00003816805,0.8725803,0.00001098106,0.007477218,0.0003751088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980501,0.0007490538,0.00001692243,0.0001842222,0.0001889984,0.0005417048,0.00003482187,0.00001755619,0.0002166357],"genre_scores_gemma":[0.9974815,0.0006048633,0.0002514171,0.00005218541,0.00008189691,0.00002548325,0.0001733737,0.00003010463,0.001299152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0182354,"threshold_uncertainty_score":0.9016513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00868911356882523,"score_gpt":0.2561074928255653,"score_spread":0.2474183792567401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}