{"id":"W2998806622","doi":"10.1128/aac.02055-19","title":"A Dimer, but Not Monomer, of Tobramycin Potentiates Ceftolozane against Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa and Delays Resistance Development","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Pseudomonas aeruginosa; Tobramycin; Medicine; Tazobactam; Microbiology; Drug resistance; Pneumonia; Antibiotics; Multiple drug resistance; Drug; Pharmacology; Antibiotic resistance; Biology; Bacteria; Internal medicine; Gentamicin; Imipenem","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547647,0.0003393946,0.0003354395,0.0003545369,0.0001322326,0.000308493,0.0003071334,0.0003120929,0.002656513],"category_scores_gemma":[0.0002627236,0.0001594361,0.0001892208,0.0002033738,0.000183698,0.000216524,0.0001971224,0.0004647153,0.0009593744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001652494,"about_ca_system_score_gemma":0.0002169384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003294648,"about_ca_topic_score_gemma":0.0009629128,"domain_scores_codex":[0.9997553,0.00006447189,0.00001770657,0.00005785234,0.00006293914,0.000041624],"domain_scores_gemma":[0.9998431,0.00001397119,0.0000321219,0.00002287833,0.00001445352,0.00007339247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003450258,0.0002368833,0.0001777556,0.00003160385,0.00001030718,0.00001689178,0.000007648058,0.00005986071,0.9968831,0.00003558284,0.0001404528,0.002054886],"study_design_scores_gemma":[0.00008789969,0.002476449,0.003351105,0.00001195705,0.00002916843,0.0002953139,0.00002685298,0.0006088094,0.9885375,0.00003820256,0.004528007,0.000008629641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934356,0.001357608,0.00211462,0.0001657858,0.00009914062,0.00006623756,0.0001597617,0.0000895777,0.002511695],"genre_scores_gemma":[0.9925445,0.0005387868,0.003393694,0.0001007711,0.00003242171,0.00003198042,0.0003747674,0.00002672029,0.002956355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002656513,"threshold_uncertainty_score":0.008886933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073026041358324,"score_gpt":0.2184265074056596,"score_spread":0.2076962469920764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}