{"id":"W2998813768","doi":"10.1530/erc-19-0448","title":"Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cells","year":2020,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Medical Research Council; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Wellcome Trust; Genome Canada; Ontario Genomics; Pfizer","keywords":"Somatostatin receptor 2; Propidium iodide; Corticotropic cell; Apoptosis; Molecular biology; Cell cycle; Flow cytometry; Somatostatin; Adrenocorticotropic hormone; Cancer research; Biology; Somatostatin receptor; Chemistry; Endocrinology; Biochemistry; Hormone; Anterior pituitary","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483631,0.0004052945,0.0004168947,0.0002627015,0.0001709256,0.0002248239,0.0001444125,0.0002462866,0.001948097],"category_scores_gemma":[0.0001048028,0.0000963724,0.0003660271,0.0002254473,0.0001488358,0.0001363922,0.0001358774,0.000609445,0.00039264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001673319,"about_ca_system_score_gemma":0.0001664803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005829164,"about_ca_topic_score_gemma":0.001589689,"domain_scores_codex":[0.9998367,0.00002258634,0.00001504577,0.00003391148,0.00005562906,0.00003611363],"domain_scores_gemma":[0.999905,0.00003117083,0.00001829729,0.00001095451,0.00001557542,0.00001891582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001937844,0.00007294891,0.0001139119,0.00006486508,0.00000913255,0.00005056234,0.00002026174,0.00007124057,0.9973617,0.00003867048,0.00005786246,0.001945029],"study_design_scores_gemma":[0.00004619281,0.001647256,0.004627234,0.000008730503,0.00003070483,0.0002282069,0.00003830074,0.0005341959,0.9891086,0.0000266251,0.003698468,0.000005504196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880992,0.005921212,0.001695195,0.0001306063,0.000107186,0.00007857808,0.000935454,0.0001095895,0.00292309],"genre_scores_gemma":[0.9866317,0.004593133,0.002399354,0.0001348195,0.00003007395,0.0001422455,0.001830352,0.00002555097,0.004212736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001948097,"threshold_uncertainty_score":0.006516993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005619348997792304,"score_gpt":0.2212399466130169,"score_spread":0.2156205976152246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}