{"id":"W2998832889","doi":"10.3390/molecules25020265","title":"Rationally Designed Ruthenium Complexes for Breast Cancer Therapy","year":2020,"lang":"en","type":"review","venue":"Molecules","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Institut national de la recherche scientifique; Armand-Frappier Foundation","keywords":"Ruthenium; Breast cancer; Triple-negative breast cancer; Estrogen receptor; Cancer; Cancer research; Drug discovery; Drug; Progesterone receptor; Chemistry; Medicine; Oncology; Combinatorial chemistry; Bioinformatics; Internal medicine; Pharmacology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001247442,0.0004142491,0.001720577,0.00008573182,0.0001086104,0.00005895027,0.0002093932,0.0001462835,0.0006241048],"category_scores_gemma":[0.00004917505,0.0002606313,0.0007165165,0.000129452,0.00009126762,0.00002894324,0.00003652593,0.0001497427,0.00005828357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005500318,"about_ca_system_score_gemma":0.0004759224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001603049,"about_ca_topic_score_gemma":0.000003086976,"domain_scores_codex":[0.9984862,0.0001466428,0.0004789751,0.0004051688,0.0002497971,0.0002331765],"domain_scores_gemma":[0.9990694,0.0001888445,0.0002089097,0.0002704893,0.0001409664,0.0001213732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001842426,0.00004994182,8.746017e-7,0.007086085,0.0005399939,0.000005971923,0.00003880803,2.433403e-7,0.001329311,0.001035368,0.00364678,0.9860824],"study_design_scores_gemma":[0.0003383856,0.0001473589,0.00001417807,0.003820305,0.0006635158,0.00007224316,0.000005599559,0.00002071687,0.000262436,0.0001020033,0.9942667,0.0002865957],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000003393713,0.9941082,0.001645348,0.00108469,0.0001211445,0.001724931,0.0007425676,0.00006750268,0.0005022266],"genre_scores_gemma":[0.0000272765,0.9938378,0.002697502,0.0007444369,0.0005654617,0.000814899,0.0002471895,0.0001069454,0.0009585136],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9906199,"threshold_uncertainty_score":0.9999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1547889221440193,"score_gpt":0.367566053070829,"score_spread":0.2127771309268097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}