{"id":"W2998832889","doi":"10.3390/molecules25020265","title":"Rationally Designed Ruthenium Complexes for Breast Cancer Therapy","year":2020,"lang":"en","type":"review","venue":"Molecules","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Institut national de la recherche scientifique; Armand-Frappier Foundation","keywords":"Ruthenium; Breast cancer; Triple-negative breast cancer; Estrogen receptor; Cancer; Cancer research; Drug discovery; Drug; Progesterone receptor; Chemistry; Medicine; Oncology; Combinatorial chemistry; Bioinformatics; Internal medicine; Pharmacology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002544408,0.0006484829,0.0006320776,0.0008829425,0.0001826308,0.0005046357,0.0005811354,0.0006728368,0.002277109],"category_scores_gemma":[0.0002055085,0.0003325875,0.0004047602,0.0007273884,0.0002101474,0.0005771082,0.0004220216,0.0009322797,0.001390666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004498113,"about_ca_system_score_gemma":0.0003314985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004386676,"about_ca_topic_score_gemma":0.0008820157,"domain_scores_codex":[0.9998794,0.00002133784,0.00001012783,0.00002752302,0.00004100976,0.00002061515],"domain_scores_gemma":[0.9999689,0.00001029295,0.000007953085,0.000001939529,0.000007777977,0.000003148406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002141182,0.0002967009,0.0002605034,0.03812224,0.0001914584,0.0007721001,0.0002187372,0.004761672,0.1636698,0.03256119,0.02492245,0.7340091],"study_design_scores_gemma":[0.00004169677,0.0003497322,0.0003399948,0.000985419,0.0001006619,0.001104851,0.00004646077,0.001028711,0.05150373,0.001921333,0.9425431,0.00003437506],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006377606,0.9782719,0.004250087,0.0004543154,0.0003643542,0.00008081875,0.0001122392,0.00008245214,0.01000619],"genre_scores_gemma":[0.0375584,0.9516127,0.004614345,0.0003857314,0.0001325967,0.00007650594,0.0001595181,0.00001951114,0.005440799],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002277109,"threshold_uncertainty_score":0.007617652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1547889221440193,"score_gpt":0.367566053070829,"score_spread":0.2127771309268097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}