{"id":"W2998835049","doi":"10.1021/acs.molpharmaceut.9b00968","title":"Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic–Pharmacodynamic Modeling for Evaluation of Treatments against Chronic <i>Pseudomonas aeruginosa</i> Lung Infections","year":2020,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Vetenskapsrådet; Joint Programming Initiative on Antimicrobial Resistance","keywords":"Pseudomonas aeruginosa; Pharmacodynamics; Pharmacokinetics; Pharmacology; Medicine; Drug; Lung; Drug development; Intensive care medicine; Biology; Internal medicine; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004914478,0.0003573242,0.0004253412,0.0003006781,0.0001309874,0.00001558806,0.0001413913,0.0001124185,0.00004461037],"category_scores_gemma":[0.0000668103,0.0003757979,0.0001986722,0.0004662175,0.00004150979,0.000139576,0.00007931606,0.0003123474,0.00001267141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001044055,"about_ca_system_score_gemma":0.001643024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004367514,"about_ca_topic_score_gemma":0.000004025414,"domain_scores_codex":[0.997416,0.0001306211,0.0008028474,0.0004403703,0.0007700294,0.0004401418],"domain_scores_gemma":[0.9986936,0.00004979544,0.0002004775,0.0001872104,0.0005762675,0.0002926155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002245802,0.0003048914,0.0001527914,0.0004976948,0.0002320383,0.00003132819,0.0004759342,0.6153361,0.3712195,0.00001729496,0.00005236831,0.01145538],"study_design_scores_gemma":[0.007061185,0.00004757454,0.000005260411,0.0001237246,0.0009070146,0.000008390506,0.00004762238,0.7384625,0.2526906,0.00001067787,0.0003936685,0.000241753],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9450293,0.001935817,0.04857216,0.0002992571,0.0001828675,0.002877458,0.00005087054,0.00009906352,0.0009532011],"genre_scores_gemma":[0.9949405,0.0004535909,0.001803231,0.001934923,0.00008049967,0.0003311744,0.0003444656,0.00007012446,0.00004145081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1231264,"threshold_uncertainty_score":0.9998694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05797396578138789,"score_gpt":0.3541355460013218,"score_spread":0.2961615802199339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}