{"id":"W2998852845","doi":"10.1038/s41420-020-0237-8","title":"Preclinical studies reveal MLN4924 is a promising new retinoblastoma therapy","year":2020,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Krembil Foundation; Government of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Cullin; Neddylation; Ubiquitin ligase; NEDD8; Cancer research; Retinoblastoma; Biology; Ubiquitin; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855365,0.0004146988,0.0002515137,0.0002917381,0.0001087023,0.0003919301,0.0002619662,0.0003406215,0.005244779],"category_scores_gemma":[0.00008756786,0.00009245198,0.0002496801,0.0001166943,0.0001570759,0.0002265082,0.0001274702,0.000819125,0.001080396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003113452,"about_ca_system_score_gemma":0.0002232192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004437295,"about_ca_topic_score_gemma":0.001684158,"domain_scores_codex":[0.999951,0.000009381722,0.00000316626,0.000008918135,0.00001529837,0.00001224381],"domain_scores_gemma":[0.9999533,0.000005838504,0.00001203448,0.000004555548,0.000005882371,0.0000184414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002233583,0.002050583,0.001552755,0.0005500516,0.0001436025,0.0004139806,0.0000526499,0.001873901,0.8229491,0.002064841,0.006948355,0.1591666],"study_design_scores_gemma":[0.003030938,0.04986716,0.01940661,0.0002548684,0.0002987957,0.002705467,0.0001298714,0.004649306,0.7151046,0.001474146,0.2030241,0.0000540698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8762994,0.06483819,0.009468595,0.003634138,0.0004850159,0.0008355986,0.004589862,0.001337211,0.03851205],"genre_scores_gemma":[0.9594813,0.01770288,0.002135335,0.0006425068,0.00005504569,0.0001772109,0.002611419,0.00005176467,0.01714258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005244779,"threshold_uncertainty_score":0.01754558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08397160906135813,"score_gpt":0.3213019188394206,"score_spread":0.2373303097780624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}