{"id":"W2998852845","doi":"10.1038/s41420-020-0237-8","title":"Preclinical studies reveal MLN4924 is a promising new retinoblastoma therapy","year":2020,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Krembil Foundation; Government of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Cullin; Neddylation; Ubiquitin ligase; NEDD8; Cancer research; Retinoblastoma; Biology; Ubiquitin; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001411645,0.0002269561,0.0002497935,0.00001412941,0.00008897985,0.00007129674,0.0002339763,0.0001578507,0.00003800751],"category_scores_gemma":[0.0001539552,0.0001928838,0.0001871761,0.00007206748,0.0000673866,0.00001269101,0.0001951377,0.0001612785,0.0000571984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001086571,"about_ca_system_score_gemma":0.0001892759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005650949,"about_ca_topic_score_gemma":0.000001229834,"domain_scores_codex":[0.9986182,0.00008481168,0.0002851597,0.0005603456,0.0001566767,0.0002947675],"domain_scores_gemma":[0.9993079,0.00003106238,0.0001065782,0.0003180723,0.00004722054,0.0001891915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009658561,0.0001245453,0.007406607,0.0001545908,0.0001804522,0.00002095479,0.001498393,0.000009763676,0.9127093,0.00006388766,0.07066249,0.006203136],"study_design_scores_gemma":[0.001086768,0.001017921,0.0009216261,0.00004736423,0.00002256687,0.000006153532,0.0001559922,0.00001843353,0.9332749,0.0002752133,0.06286702,0.0003060615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822374,0.01133272,0.0005272523,0.001705139,0.0001700632,0.0003868508,0.00003030997,0.00003456587,0.003575692],"genre_scores_gemma":[0.9821556,0.002425534,0.001314345,0.006206442,0.00129219,0.00002452808,0.00004109355,0.00004437496,0.006495894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02056556,"threshold_uncertainty_score":0.7865576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08397160906135813,"score_gpt":0.3213019188394206,"score_spread":0.2373303097780624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}