{"id":"W2998875317","doi":"10.3324/haematol.2019.226126","title":"HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development","year":2020,"lang":"en","type":"article","venue":"Haematologica","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; European Hematology Association","keywords":"HES1; Haematopoiesis; Biology; Progenitor cell; Notch signaling pathway; Cell biology; Myeloid; Lineage (genetic); Gene knockdown; Lymphopoiesis; Stem cell; T cell; Cellular differentiation; Psychological repression; Genetics; Cancer research; Gene; Signal transduction; Gene expression; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006101351,0.00015004,0.0002166978,0.00002315106,0.000130177,0.000009483681,0.0001143956,0.0001678109,0.00001866022],"category_scores_gemma":[0.00001309122,0.0001251649,0.00004177264,0.00003989954,0.0001202128,0.000003434045,0.0001598623,0.00005764534,0.0000120704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005401813,"about_ca_system_score_gemma":0.00003347529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000049312,"about_ca_topic_score_gemma":0.00001701719,"domain_scores_codex":[0.9991391,0.00002905123,0.0002576467,0.0003239853,0.00007218133,0.0001780303],"domain_scores_gemma":[0.9996533,0.000005385843,0.0001087066,0.0001173556,0.00003239058,0.00008289398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008790429,0.00004649857,0.07074309,0.00007929727,0.00003794733,0.00001123348,0.000407409,0.000003027018,0.9278126,0.00004222051,0.00007753859,0.0006511873],"study_design_scores_gemma":[0.0003915003,0.0001590353,0.1703377,0.00001415529,0.000007134396,0.00002659825,0.00009750601,0.000003760746,0.827981,0.00002947699,0.0008067368,0.0001453553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981124,0.0003185,0.00009547869,0.0001245858,0.00001973788,0.0001490385,0.000004512468,0.00001306725,0.001162725],"genre_scores_gemma":[0.9977401,0.00003657304,0.001841552,0.00009486776,0.00002650537,0.00001421808,0.00007570159,0.000008451565,0.0001620116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09983163,"threshold_uncertainty_score":0.5104076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014183493213939,"score_gpt":0.2184231165794869,"score_spread":0.2082812816473475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}