{"id":"W2998875317","doi":"10.3324/haematol.2019.226126","title":"HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development","year":2020,"lang":"en","type":"article","venue":"Haematologica","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; European Hematology Association","keywords":"HES1; Haematopoiesis; Biology; Progenitor cell; Notch signaling pathway; Cell biology; Myeloid; Lineage (genetic); Gene knockdown; Lymphopoiesis; Stem cell; T cell; Cellular differentiation; Psychological repression; Genetics; Cancer research; Gene; Signal transduction; Gene expression; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001076911,0.0002160586,0.0001506291,0.0001723982,0.0001143337,0.0002925628,0.0001606386,0.0001529981,0.001183115],"category_scores_gemma":[0.00008880367,0.0001250987,0.0001423246,0.000151939,0.0001698037,0.0001436056,0.0001637282,0.0001727593,0.0005801672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001565002,"about_ca_system_score_gemma":0.0001806386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002786148,"about_ca_topic_score_gemma":0.0002944865,"domain_scores_codex":[0.999898,0.00001731332,0.000009325936,0.00002507645,0.00003113131,0.0000192882],"domain_scores_gemma":[0.9999495,0.000008133807,0.00001747443,0.000006359565,0.000008193912,0.00001025407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001239073,0.000007312536,0.0009246508,0.00005559353,0.000006519727,0.00009568142,0.00002378981,0.0002020933,0.994112,0.00015113,0.00004876221,0.004248505],"study_design_scores_gemma":[0.000007100021,0.0001157915,0.01420879,0.000007658131,0.00002430525,0.0006843089,0.00003945835,0.0006529759,0.9792085,0.0001160884,0.004929423,0.000005564989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882301,0.003985545,0.004756455,0.00006838079,0.0000119921,0.00001971698,0.0005994703,0.0001361732,0.002192159],"genre_scores_gemma":[0.9912788,0.001911459,0.00234364,0.00004304626,0.000006250744,0.00001975574,0.0007529447,0.00002107159,0.003622938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001183115,"threshold_uncertainty_score":0.003957927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014183493213939,"score_gpt":0.2184231165794869,"score_spread":0.2082812816473475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}