{"id":"W2998880438","doi":"10.1038/s41436-019-0718-4","title":"Assessment of laboratories offering cell-free (cf) DNA screening for Down syndrome: results of the 2018 College of American Pathology External Educational Exercises","year":2020,"lang":"en","type":"article","venue":"Genetics in Medicine","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"Trisomy; Genotyping; Cell-free fetal DNA; Medicine; Test (biology); Medical physics; Pediatrics; Prenatal diagnosis; Fetus; Genetics; Pregnancy; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003640512,0.0001302668,0.0005773468,0.00008558773,0.00002871117,0.000001123198,0.000300233,0.00005793032,0.00001570625],"category_scores_gemma":[0.00224108,0.00009492198,0.00005367293,0.0004870059,0.0005758708,0.00001460774,0.0001637421,0.0001545268,1.148525e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002511963,"about_ca_system_score_gemma":0.0002696176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001172765,"about_ca_topic_score_gemma":0.00002563279,"domain_scores_codex":[0.9984442,0.00006227913,0.0006764163,0.0002150999,0.0004270321,0.0001749753],"domain_scores_gemma":[0.9980796,0.000720397,0.0004388619,0.0004138006,0.000243187,0.0001041694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002175063,0.0007692816,0.782226,0.00242985,0.0001535271,0.00008328936,0.003206769,0.00216565,0.1848447,0.002365589,0.01433546,0.005244874],"study_design_scores_gemma":[0.005868345,0.002858682,0.9341943,0.001331446,0.0002274025,0.00003213205,0.001585311,0.001038102,0.05190814,0.0004467753,0.0003868836,0.0001224688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882454,0.001214984,0.003836677,0.004755267,0.0002289678,0.0004821194,0.000807119,0.000007534312,0.0004219627],"genre_scores_gemma":[0.9516137,0.0002567134,0.04764378,0.0002287913,0.0001558597,0.0000198883,0.0000337509,0.00001479538,0.00003273434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1519684,"threshold_uncertainty_score":0.3870806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0289190110331253,"score_gpt":0.3195263007597658,"score_spread":0.2906072897266406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}